pH Tunable Turn on and Turn off Quantum Dots Conjugated with Poly(2-(Dialkylamino)ethyl Methacrylate)

Abstract:

A novel pH sensitive cadmium sulfide quantum dot (CdS QD) was prepared by a coprecipitation method in the presence of pH sensitive poly (2-(dimethylamino) ethyl methacrylate)-co-poly (2-(dibutylamino) ethyl methacrylate)(PDMA-PDBA) copolymer. CdCl₂ and Na₂S were mixed in aqueous media in the presence of PDMA-PDBA. The amine groups of PDMA were anchored on the surface of the formed CdS nanoparticles, whereas the PDBA segment was anchored on the surface to form a hydrophilic palisade at low pH environment, thus turn on the fluorescence CdS QD probe; at high pH value, PDBA segments precipitate and turn off fluorescence because of the phase separation. This novel pH sensitive fluorescene CdS QDs probe have great application potential for target imaging of cancer.

• Periodical: Advanced Materials Research (Volumes 998-999)
• Pages: 75-78
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.998-999.75
• Online since: July 2014
• Authors: Xian Nan Huang*, Wei Li, Wei He
• Keywords: Fluorescence, pH Sensitive, Poly(2-(Dialkylamino)Ethyl Methacrylate), Quantum Dot (QD)

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