Fabrication of Chemically Linked PEGylated Prodrugs for Hydrogel Carriers

Tian Le Wang

doi:10.4028/www.scientific.net/AST.105.42

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HomeAdvances in Science and TechnologyAdvances in Science and Technology Vol. 105Fabrication of Chemically Linked PEGylated...

Fabrication of Chemically Linked PEGylated Prodrugs for Hydrogel Carriers

Abstract:

Some hydrophilic drugs (e.g. anti-tumor drug of doxorubicin (DOX) and anti-osteoporosis drug of alendronate sodium (ALN)) have great toxic and adverse effects on the human body. In this paper, two kinds of drug-loaded composite gel systems were prepared via mild and efficient chemical reaction synthesis, hyaluronic acid-linked ALN (HA-ALN) hydrogel and polyethylene glycol-linked DOX (Tetra-PEG-DOX) hydrogel. By characterizing their chemical structures, morphological networks, and ultraviolet absorption behaviors, two different types of drug-loaded composite gels can be constructed well. It is expected to achieve effective drug loading and controlled release. The two drug-loaded gels are applied in the fields of antitumor and anti-osteoporosis and exert their application value in the field of biomedicine.

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Periodical:

Advances in Science and Technology (Volume 105)

Pages:

42-47

DOI:

https://doi.org/10.4028/www.scientific.net/AST.105.42

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Online since:

April 2021

Authors:

Tian Le Wang*

Keywords:

Doxorubicin, Hyaluronic Acid-Linked Alendronate Sodium, Hydrogel, T Polyethylene Glycol-Linked Doxorubicin

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* - Corresponding Author

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