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Effect of Citric Acid Treatment on Doxycycline Sorption of Chitosan Hydrogel

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Abstract:

The development of chitosan hydrogels for open wound treatment shows promise due to their antibacterial properties, moisture retention, antibiotic loading and release capabilities, and potential for cross-linking modifications. This study investigates the effect of citric acid cross-linking on the sorption behavior of doxycycline in pH-gelated chitosan hydrogels by modeling sorption isotherms and evaluating antibacterial activity through measurements of zones of inhibition. Chitosan hydrogels were prepared via pH-induced gelation using 1.0 % v/v acetic acid and 2.5 M sodium hydroxide. Citric acid cross-linking was facilitated by adding citric acid at concentrations of 0%, 1%, 3%, and 6% (w/v). Results showed that the Dubinin-Radushkevich isotherm best described the sorption for 0%, 3%, and 6% citric acid gels, attributed to microporous structures and energy heterogeneity of the adsorption sites, while the Toth isotherm fit the 1% gel. Citric acid concentration did not significantly affect the antibacterial efficacy of the hydrogels, suggesting that cross-linking can improve mechanical properties without negating the antibacterial activity of doxycycline.

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Periodical:

Advances in Science and Technology (Volume 180)

Pages:

31-36

DOI:

https://doi.org/10.4028/p-45GqhQ

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Online since:

July 2026

Authors:

Charlimagne M. Montealegre*, John Vince S. Manlangit, Calvin Luis A. Masiglat, Enrico Fernando C. Taleon

Keywords:

Antimicrobial Assay, Chitosan Hydrogels, Citric Acid Treatment, pH-Induced Gelation, Sorption Isotherms

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© 2026 Trans Tech Publications Ltd. All Rights Reserved

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