Inhibition of Alzheimer Amyloid Aggregation with Sulfate Glycopolymers

Yoshiko Miura; Kiyofumi Yamamoto; Kikuko Yasuda; Yoshihiro Nishida; Kazukiyo Kobayashi

doi:10.4028/www.scientific.net/AST.57.166

Paper Titles

Supramolecular Approach to Gene Delivery
p.144

A New Drug Vehicle - Lipid Coated Biodegradable Nanoparticles
p.148

Base Invaders. Coupling Experiments and Multiscale Modeling of Dendrimer-Based siRNA Delivery Agents
p.154

Trastuzumab Decorated Nanoparticles for Targeted Chemotherapy of Breast Cancer
p.160

Inhibition of Alzheimer Amyloid Aggregation with Sulfate Glycopolymers
p.166

Electrical Field Responsive Polypyrole in Poly(Acrylic Acid) Hydrogel for Transdermal Drug Delivery
p.170

Preparation and Characterization of Highly Water Soluble Drug Loaded PLA Microcapsules
p.176

Effect of Electric Field Strength on the Diffusion of Salicylic Acid through Polyacrylamide Hydrogels
p.182

New Antibacterial, Antiadhesive Films Based on Self Assemblies of Modified Tetraetherlipids
p.188

HomeAdvances in Science and TechnologyAdvances in Science and Technology Vol. 57Inhibition of Alzheimer Amyloid Aggregation with...

Inhibition of Alzheimer Amyloid Aggregation with Sulfate Glycopolymers

Abstract:

Glycopolymers carrying sulfate saccharides were found to suppress the formation of amyloid fibrils by amyloid beta peptides, as evaluated by fluorescence assay of thioflavin T and AFM. CD spectra showed that the conformation of amyloid beta peptides was changed from beta peptides depended on the glycopolymer additives, and that the glycopolymer additives reduced the β-sheet contents. Neutralization activity was confirmed by in vitro assay with HeLa cells. The sulfate group and the appropriate sugar contents were essential for the inhibitory effect.