Inhibition of Alzheimer Amyloid Aggregation with Sulfate Glycopolymers

Abstract:

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Glycopolymers carrying sulfate saccharides were found to suppress the formation of amyloid fibrils by amyloid beta peptides, as evaluated by fluorescence assay of thioflavin T and AFM. CD spectra showed that the conformation of amyloid beta peptides was changed from beta peptides depended on the glycopolymer additives, and that the glycopolymer additives reduced the β-sheet contents. Neutralization activity was confirmed by in vitro assay with HeLa cells. The sulfate group and the appropriate sugar contents were essential for the inhibitory effect.

Info:

Periodical:

Edited by:

Pietro VINCENZINI and Danilo DE ROSSI

Pages:

166-169

DOI:

10.4028/www.scientific.net/AST.57.166

Citation:

Y. Miura et al., "Inhibition of Alzheimer Amyloid Aggregation with Sulfate Glycopolymers", Advances in Science and Technology, Vol. 57, pp. 166-169, 2008

Online since:

September 2008

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Price:

$35.00

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