Effect of Electric Field Strength on the Diffusion of Salicylic Acid through Polyacrylamide Hydrogels
The release mechanisms and the diffusion coefficients of salicylic acid -loaded polyacrylamide hydrogels are investigated experimentally by using a modified Franz-Diffusion cell at the temperature of 37 °C to determine the effects of crosslinking ratio and electric field strength. The fabricated hydrogels retain their physical shapes and sizes during the experiments along with data reproducibility. A significant amount of salicylic is released within 48 h from the hydrogels of various crosslinking ratios, with and without electric field. The release profile of Q vs. t1/2 is linear. Diffusion coefficient, determined from the Higuchi equation, increases with electric field strength and reach maximum values at electric field strength of 0.1 V due to the electrophoresis of the drug, and it becomes saturated at electric field strengths between 0.5 – 10 V.
Pietro VINCENZINI and Danilo DE ROSSI
S. Niamlang and A. Sirivat, "Effect of Electric Field Strength on the Diffusion of Salicylic Acid through Polyacrylamide Hydrogels", Advances in Science and Technology, Vol. 57, pp. 182-187, 2008