Effect of Electric Field Strength on the Diffusion of Salicylic Acid through Polyacrylamide Hydrogels

Abstract:

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The release mechanisms and the diffusion coefficients of salicylic acid -loaded polyacrylamide hydrogels are investigated experimentally by using a modified Franz-Diffusion cell at the temperature of 37 °C to determine the effects of crosslinking ratio and electric field strength. The fabricated hydrogels retain their physical shapes and sizes during the experiments along with data reproducibility. A significant amount of salicylic is released within 48 h from the hydrogels of various crosslinking ratios, with and without electric field. The release profile of Q vs. t1/2 is linear. Diffusion coefficient, determined from the Higuchi equation, increases with electric field strength and reach maximum values at electric field strength of 0.1 V due to the electrophoresis of the drug, and it becomes saturated at electric field strengths between 0.5 – 10 V.

Info:

Periodical:

Edited by:

Pietro VINCENZINI and Danilo DE ROSSI

Pages:

182-187

DOI:

10.4028/www.scientific.net/AST.57.182

Citation:

S. Niamlang and A. Sirivat, "Effect of Electric Field Strength on the Diffusion of Salicylic Acid through Polyacrylamide Hydrogels", Advances in Science and Technology, Vol. 57, pp. 182-187, 2008

Online since:

September 2008

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$35.00

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