Effect of Electric Field Strength on the Diffusion of Salicylic Acid through Polyacrylamide Hydrogels

Abstract:

The release mechanisms and the diffusion coefficients of salicylic acid -loaded polyacrylamide hydrogels are investigated experimentally by using a modified Franz-Diffusion cell at the temperature of 37 °C to determine the effects of crosslinking ratio and electric field strength. The fabricated hydrogels retain their physical shapes and sizes during the experiments along with data reproducibility. A significant amount of salicylic is released within 48 h from the hydrogels of various crosslinking ratios, with and without electric field. The release profile of Q vs. t1/2 is linear. Diffusion coefficient, determined from the Higuchi equation, increases with electric field strength and reach maximum values at electric field strength of 0.1 V due to the electrophoresis of the drug, and it becomes saturated at electric field strengths between 0.5 – 10 V.

• Periodical: Advances in Science and Technology (Volume 57)
• Pages: 182-187
• DOI: https://doi.org/10.4028/www.scientific.net/AST.57.182
• Online since: September 2008
• Authors: Sumonman Niamlang, Anuvat Sirivat
• Keywords: Controlled Drug Release, Diffusion Coefficient, Electroresponsive Hydrogel, Polyacrylamide Hydrogel

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