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Supramolecular Surfaces Modulating Cellular Response
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Supramolecular Surfaces Modulating Cellular Response

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Abstract:

Polyrotaxane-immobilized surfaces were prepared as a platform of dynamic surfaces, which can prevent from non-specific interaction with plasma proteins and platelet, and then modulate cellular functions via specific interaction with receptor protein-ligand binding through movable polyrotaxane backbone. The immobilization of the polyrotaxane was carried out via two-step protocol, in which the polyrotaxane with tetraethyleneglycol dodecanethiol (TEGDT) anchoring group at both terminals was fixed onto Au substrate via Au-S bond, followed by the fixation of TEGDT molecule onto the Au substrate to complete the loop formation of polyrotaxane on the Au substrate with the help of self-assembled monolayer formation of TEGDT. Their surface properties were characterized by means dynamic contact angle measurements, and preliminary studies as biomaterials were performed in terms of plasma protein adsorption onto their surfaces.

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Periodical:

Advances in Science and Technology (Volume 76)

Pages:

10-15

DOI:

https://doi.org/10.4028/www.scientific.net/AST.76.10

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Online since:

October 2010

Authors:

Nobuhiko Yui

Keywords:

Biomaterial, Cyclodextrin, Fibrinogen, Platelet, Polyrotaxane

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© 2010 Trans Tech Publications Ltd. All Rights Reserved

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