Supramolecular Surfaces Modulating Cellular Response

Abstract:

Article Preview

Polyrotaxane-immobilized surfaces were prepared as a platform of dynamic surfaces, which can prevent from non-specific interaction with plasma proteins and platelet, and then modulate cellular functions via specific interaction with receptor protein-ligand binding through movable polyrotaxane backbone. The immobilization of the polyrotaxane was carried out via two-step protocol, in which the polyrotaxane with tetraethyleneglycol dodecanethiol (TEGDT) anchoring group at both terminals was fixed onto Au substrate via Au-S bond, followed by the fixation of TEGDT molecule onto the Au substrate to complete the loop formation of polyrotaxane on the Au substrate with the help of self-assembled monolayer formation of TEGDT. Their surface properties were characterized by means dynamic contact angle measurements, and preliminary studies as biomaterials were performed in terms of plasma protein adsorption onto their surfaces.

Info:

Periodical:

Edited by:

Pietro VINCENZINI, John A. JANSEN, Kazuhiko ISHIHARA and Thomas J. WEBSTER

Pages:

10-15

DOI:

10.4028/www.scientific.net/AST.76.10

Citation:

N. Yui "Supramolecular Surfaces Modulating Cellular Response", Advances in Science and Technology, Vol. 76, pp. 10-15, 2010

Online since:

October 2010

Authors:

Export:

Price:

$35.00

In order to see related information, you need to Login.

In order to see related information, you need to Login.