A Hydroxyapatite-Collagen Composite Useful to Make Bioresorbable Scaffolds for Bone Reconstruction

Abstract:

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Composites between hydroxyapatite (HA) and collagen (Col) may be used to make bioresorbable scaffolds for bone reconstruction. A suspension of micro-particles (average diameter ≅ 30 µm) of HA annealed at 1100°C in Col solution (80:20 HA to Col weight ratio) was manufactured in films by casting, and then some films were cross-linked by glutaraldehyde vapours. Cross-linked sponges were obtained by treating the suspension with transglutaminase, and by lyophilizing the so obtained gel. Characterization by scanning electron microscopy, water sorption test, Col release in water, thermogravimetric analysis and differential scanning calorimetry shows that the cross-linking enhances the stability of the composite. Conversely, neither the interactions between HA and Col, detected by spotlight FT-IR, nor the degradation by collagenase, which is a requirement for the bioresorbibility, are affected by the cross-linking.

Info:

Periodical:

Edited by:

Pietro VINCENZINI, John A. JANSEN, Kazuhiko ISHIHARA and Thomas J. WEBSTER

Pages:

133-138

DOI:

10.4028/www.scientific.net/AST.76.133

Citation:

G. D. Guerra et al., "A Hydroxyapatite-Collagen Composite Useful to Make Bioresorbable Scaffolds for Bone Reconstruction", Advances in Science and Technology, Vol. 76, pp. 133-138, 2010

Online since:

October 2010

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Price:

$35.00

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