XPS Characterization of Iron Oxide and Gold Nanoparticles for Tumor Care

Abstract:

Superparamagnetic iron oxide nanoparticles (SPIO) have a wide range of applications, including high-density magnetic storage, catalytic and separation processes, magnetic resonance imaging (MRI), in vivo imaging of tumor progression. One advantage is that they are sufficiently inert to be injected to the human body without significant counter effects. For these reasons, SPIO are utilized as carriers to target tumor tissues with the aim to visualize the extension of the malignant affection and to cure it. A mimetic coating is needed to overcome the immune system and ensure a sufficient long life to allow SPIO to reach the tumor tissue. In addition, gold nanoparticles were functionalized and coated with the same mimetic film. Differently from iron oxide NPs, those based on gold may be utilized to perform Surface Enhanced Raman Spectroscopy (SERS) to obtain spatial and chemical information. In this work, we present preliminary results on iron oxide and gold-based NPs synthesized in our laboratories. A full characterization was performed by means of XPS to study both the chemical composition of the SPIO nanoparticles, of their mimetic coatings, and to get structural information.

• Periodical: Advances in Science and Technology (Volume 76)
• Pages: 165-170
• DOI: https://doi.org/10.4028/www.scientific.net/AST.76.165
• Online since: October 2010
• Authors: Giorgio Speranza, L. Minati, Simona Torrengo, Barbara Rossi, Claudio Migliaresi, Devid Maniglio, Luca Dalbosco
• Keywords: Gold Nanoparticles (GNP), Superparamagnetic Iron Oxide Nanoparticle, X-Ray Photoelectron Spectroscopy (XPS)

References

[1] M. Zhao, M. F. Kircher, L. Josephson, R. Weissleder Bioconjug Chem Vol. 13, (2002), p.840.

[2] J. W. M. Bulte, T. Douglas, B. Witwer, S. C. Zhang, E. Strable Nat. Biotechnol Vol. 19, (2001), p.1141.

[3] M. Lewin, N. Carlesso, C.H. Tung, X. W., Tang, D. Cory Nat Biotechnol Vol 18, (2000), p.410.

[4] G.M. Lanza, D.R. Abendschein, X. Yu, PM Winter, K. K. Karukstis, M. J. Scott, R. W. Fuhrhop, D. E Scherrer, S. A. Wickline, Aca. Radiol. Vol. 9, (2002), p. S330.

DOI: 10.1016/s1076-6332(03)80220-9

[5] C. Sun, J. S. H. Lee, M.Q. Zhang. Adv Drug Deliver Rev. Vol. 60, (2008), p.1252.

[6] Y. H. Chatterjee, C. Chen, , J. Magn. Mater. Vol. 257, (2003), p.113.

[7] X. -M. Qian, S. M. Nie Chem. Soc. Rev., Vol. 37, (2008), p.912.

[8] C. Sun, O. Veiseh, J. Gunn, C. Fang, S. Hansen, D. Lee, R. Sze, R.G. Ellenbogen, J. Olson, M. Zhang Small Vol. 4, (2008), p.372.

DOI: 10.1002/smll.200700784

[9] Y. Cheng, A. C. Samia, J. D. Meyers, I. Panagopoulos, B. Fei, C. Burda J. Am. Chem. Soc. Vol 130, (2008), p.10643.

[10] W. Z. Lin Wang, Nano Res. Vol 1, (2008), p.99.

[11] B. Thierry, F. Al-Ejeh, A. Khatri, Z. Yuan, P. J. Russell, S. Ping, M. P. Brown, P. Majewski Chem. Commun. Vol 47, (2009), p.7348.

DOI: 10.1039/b911703b

[12] informations on http: /srdata. nist. gov/xps.

[13] L. -V. Daimay, The Handbook of infrared and Raman characteristic frequencies of organic molecules Academic Press Boston (1991).

[14] A. Campion, P. Kambhampati, Chem. Soc. Rev. Vol. 27 (1998), p.241.