Novel Silicon Based Gene Carrier Systems

Abstract:

The preparation and charactersiation of novel gene vehicles based on synthetic organic silicon derivatives are which are formulated as solid lipid nanoparticles (SLN) and liposomes are investigated in the presented study. Physicochemical parameters and morphology were studied by photon correlation spectroscopy, zeta potential measurements (NanoZ Malvern) and Atomic Force Microscopy (Digital Nanoscope IV Bioscope), while the biological activity was determined using a standard in vitro transfection assay and corelated with established gene transfection systems.

• Periodical: Advances in Science and Technology (Volume 76)
• Pages: 171-176
• DOI: https://doi.org/10.4028/www.scientific.net/AST.76.171
• Online since: October 2010
• Authors: Anett Sommerwerk, Guido Struckmeyer, Janine Tillmann, Michael Uhr, J. Schäfer, Heinrich Richter, Udo Bakowsky
• Keywords: Atomic Force Microscope (AFM), Gene Transfection, Lipid Derivative, Liposome, Silicon

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