Novel Silicon Based Gene Carrier Systems
The preparation and charactersiation of novel gene vehicles based on synthetic organic silicon derivatives are which are formulated as solid lipid nanoparticles (SLN) and liposomes are investigated in the presented study. Physicochemical parameters and morphology were studied by photon correlation spectroscopy, zeta potential measurements (NanoZ Malvern) and Atomic Force Microscopy (Digital Nanoscope IV Bioscope), while the biological activity was determined using a standard in vitro transfection assay and corelated with established gene transfection systems.
Pietro VINCENZINI, John A. JANSEN, Kazuhiko ISHIHARA and Thomas J. WEBSTER
A. Sommerwerk et al., "Novel Silicon Based Gene Carrier Systems", Advances in Science and Technology, Vol. 76, pp. 171-176, 2010