Novel Silicon Based Gene Carrier Systems

Abstract:

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The preparation and charactersiation of novel gene vehicles based on synthetic organic silicon derivatives are which are formulated as solid lipid nanoparticles (SLN) and liposomes are investigated in the presented study. Physicochemical parameters and morphology were studied by photon correlation spectroscopy, zeta potential measurements (NanoZ Malvern) and Atomic Force Microscopy (Digital Nanoscope IV Bioscope), while the biological activity was determined using a standard in vitro transfection assay and corelated with established gene transfection systems.

Info:

Periodical:

Edited by:

Pietro VINCENZINI, John A. JANSEN, Kazuhiko ISHIHARA and Thomas J. WEBSTER

Pages:

171-176

DOI:

10.4028/www.scientific.net/AST.76.171

Citation:

A. Sommerwerk et al., "Novel Silicon Based Gene Carrier Systems", Advances in Science and Technology, Vol. 76, pp. 171-176, 2010

Online since:

October 2010

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Price:

$35.00

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