Porous Silicas for Enhanced Drug Release

Abina M. Crean; Robert J. Ahern; Rakesh Dontireddy; Walid Faisil; John P. Hanrahan; Brendan T. Griffin; Katie B. Ryan

doi:10.4028/www.scientific.net/AST.91.79

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HomeAdvances in Science and TechnologyAdvances in Science and Technology Vol. 91Porous Silicas for Enhanced Drug Release

Porous Silicas for Enhanced Drug Release

Abstract:

Low drug water-solubility is a major challenge to overcome in the development of tablet or capsule dosage forms for a large number of promising drug candidates. Strategies to improve drug solubility and dissolution involve chemical, physical and formulation approaches. An emerging formulation approach to increase drug dissolution and solubility involves the creation of solid dispersions of drug molecules on to a high surface area inorganic carrier, such as porous silica. The combined benefits of a hydrophilic inorganic substrate, increased drug surface area and a high-energy drug form facilitate rapid drug dissolution into aqueous based media and can create supersaturated drug solutions. The work presented provides a brief overview of the silica grades investigated, processes employed to load drugs onto the silica substrates, provide some examples of the ability of silica to enhance drug dissolution and highlight some of the challenges in the development of these novel drug delivery systems.

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Periodical:

Advances in Science and Technology (Volume 91)

Pages:

79-81

DOI:

https://doi.org/10.4028/www.scientific.net/AST.91.79

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Online since:

October 2014

Authors:

Abina M. Crean*, Robert J. Ahern, Rakesh Dontireddy, Walid Faisil, John P. Hanrahan, Brendan T. Griffin, Katie B. Ryan

Keywords:

Dissolution, Drug, Mesoporous, Poorly Water-Soluble, Silica

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* - Corresponding Author

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