On-Body Chemo/Bio-Sensing - Opportunities and Challenges

Abstract:

In recent years, there has been significant progress in a number of sensing technologies related to on-body measurements, such as platforms for monitoring respiration, heart rate, location and movement. In these cases, the sensing element (s) are based on highly effective transducers that are increasingly integrated into garments such that they are becoming innocuous to the user. In contrast, the area of on-body chemical sensing remains highly under-developed. In this paper, we will address the significant challenges that are inhibiting the practical realisation of reliable chemical sensors and biosensors capable of generating accurate data in real time.

• Periodical: Advances in Science and Technology (Volume 96)
• Pages: 78-88
• DOI: https://doi.org/10.4028/www.scientific.net/AST.96.78
• Online since: October 2014
• Authors: Giusy Matzeu, Cormac Fay, Conor O’Quigley, Dylan Orpen, Simon Coleman, Andrew Kavanagh, Dermot Diamond*
• Keywords: Biological Fluids, Chemical Sensors, Non-Invasive Monitoring, Wearable

References

[1] B. Latré, B. Braem, I. Moerman, C. Blondia, P. Demeester, A survey on wireless body area networks, Wireless Networks. 17 (2011) 1-18.

DOI: 10.1007/s11276-010-0252-4

[2] D. Diamond, S. Coyle, S. Scarmagnani, J. Hayes, Wireless sensor networks and chemo-/biosensing, Chem. Rev. 108 (2008) 652-679.

DOI: 10.1021/cr0681187

[3] C. Zuliani, D. Diamond, Opportunities and challenges of using ion-selective electrodes in environmental monitoring and wearable sensors, Electrochim. Acta. 84 (2012) 29-34.

DOI: 10.1016/j.electacta.2012.04.147

[4] M. Chan, D. Estève, J. Fourniols, C. Escriba, E. Campo, Smart wearable systems: Current status and future challenges, Artif. Intell. Med. 56 (2012) 137-156.

DOI: 10.1016/j.artmed.2012.09.003

[5] D. Diamond, Peer Reviewed: Internet-Scale Sensing, Anal. Chem. 76 (2004) 278 A-286 A.

DOI: 10.1021/ac041598m

[6] K.T. SATO, A. RICHARDSON, D.E. TIMM, K. SATO, One-step iodine starch method for direct visualization of sweating, Am. J. Med. Sci. 295 (1988) 528-531.

DOI: 10.1097/00000441-198806000-00006

[7] P. Lemon, K. Yarasheski, Feasibility of sweat collection by whole body washdown in moderate to high humidity environments, Int. J. Sports Med. 6 (1985) 41-43.

DOI: 10.1055/s-2008-1025811

[8] S.M. Shirreffs, R.J. Maughan, Whole body sweat collection in humans: an improved method with preliminary data on electrolyte content, J. Appl. Physiol. (1985). 82 (1997) 336-341.

DOI: 10.1152/jappl.1997.82.1.336

[9] X. Cai, J. Yan, H. Chu, M. Wu, Y. Tu, An exercise degree monitoring biosensor based on electrochemiluminescent detection of lactate in sweat, Sensors Actuators B: Chem. 143 (2010) 655-659.

DOI: 10.1016/j.snb.2009.10.002

[10] A. Caduff, M.S. Talary, M. Mueller, F. Dewarrat, J. Klisic, M. Donath, L. Heinemann, W.A. Stahel, Non-invasive glucose monitoring in patients with Type 1 diabetes: a multisensor system combining sensors for dielectric and optical characterisation of skin, Biosensors and Bioelectronics. 24 (2009).

DOI: 10.1016/j.bios.2009.02.001

[11] M. Gamella, S. Campuzano, J. Manso, G. Rivera, F. López-Colino, A. Reviejo, J. Pingarrón, A novel non-invasive electrochemical biosensing device for in situ determination of the alcohol content in blood by monitoring ethanol in sweat, Anal. Chim. Acta. 806 (2014).

DOI: 10.1016/j.aca.2013.09.020

[12] D. Morris, S. Coyle, Y. Wu, K.T. Lau, G. Wallace, D. Diamond, Bio-sensing textile based patch with integrated optical detection system for sweat monitoring, Sensors Actuators B: Chem. 139 (2009) 231-236.

DOI: 10.1016/j.snb.2009.02.032

[13] S. Coyle, K. Lau, N. Moyna, D. O'Gorman, D. Diamond, F. Di Francesco, D. Costanzo, P. Salvo, M.G. Trivella, D.E. De Rossi, BIOTEX—Biosensing textiles for personalised healthcare management, Information Technology in Biomedicine, IEEE Transactions on. 14 (2010).

DOI: 10.1109/titb.2009.2038484

[14] V.F. Curto, S. Coyle, R. Byrne, N. Angelov, D. Diamond, F. Benito-Lopez, Concept and development of an autonomous wearable micro-fluidic platform for real time pH sweat analysis, Sensors Actuators B: Chem. 175 (2012) 263-270.

DOI: 10.1016/j.snb.2012.02.010

[15] V.F. Curto, C. Fay, S. Coyle, R. Byrne, C. O'Toole, C. Barry, S. Hughes, N. Moyna, D. Diamond, F. Benito-Lopez, Real-time sweat pH monitoring based on a wearable chemical barcode micro-fluidic platform incorporating ionic liquids, Sensors Actuators B: Chem. 171 (2012).

DOI: 10.1016/j.snb.2012.06.048

[16] N. Hamouti, J. Del Coso, R. Mora-Rodriguez, Comparison between blood and urinary fluid balance indices during dehydrating exercise and the subsequent hypohydration when fluid is not restored, Eur. J. Appl. Physiol. 113 (2013) 611-620.

DOI: 10.1007/s00421-012-2467-9

[17] M.H. Schmid-Wendtner, H.C. Korting, The pH of the skin surface and its impact on the barrier function, Skin Pharmacol. Physiol. 19 (2006) 296-302.

DOI: 10.1159/000094670

[18] M.J. Patterson, S.D. Galloway, M.A. Nimmo, Variations in regional sweat composition in normal human males, Exp. Physiol. 85 (2000) 869-875.

DOI: 10.1017/s0958067000020583

[19] J.J. Hulstein, P. van 't Sant, Sweat analysis using indirect ion-selective electrode on the routine chemistry analyser meets UK guidelines, Ann. Clin. Biochem. 48 (2011) 374-376.

DOI: 10.1258/acb.2011.011001

[20] P.B. Davis, U. Yasothan, P. Kirkpatrick, Ivacaftor, Nature Reviews Drug Discovery. 11 (2012) 349-350.

DOI: 10.1038/nrd3723

[21] B. Schazmann, D. Morris, C. Slater, S. Beirne, C. Fay, R. Reuveny, N. Moyna, D. Diamond, A wearable electrochemical sensor for the real-time measurement of sweat sodium concentration, Analytical Methods. 2 (2010) 342-348.

DOI: 10.1039/b9ay00184k

[22] C. Zuliani, G. Matzeu, D. Diamond, A liquid-junction-free reference electrode based on a PEDOT solid-contact and ionogel capping membrane, Talanta. 125 (2014) 58-64.

DOI: 10.1016/j.talanta.2014.02.018

[23] B. O'Flynn, S. Bellis, K. Delaney, J. Barton, S.C. O'Mathuna, A.M. Barroso, J. Benson, U. Roedig, C. Sreenan, The development of a novel minaturized modular platform for wireless sensor networks, Information Processing in Sensor Networks, 2005.  IPSN 2005.  Fourth International Symposium on. (2005).

DOI: 10.1109/ipsn.2005.1440951

[24] T. Guinovart, M. Parrilla, G.A. Crespo, F.X. Rius, F.J. Andrade, Potentiometric sensors using cotton yarns, carbon nanotubes and polymeric membranes, Analyst. 138 (2013) 5208-5215.

DOI: 10.1039/c3an00710c

[25] D.H. Kim, N. Lu, R. Ma, Y.S. Kim, R.H. Kim, S. Wang, J. Wu, S.M. Won, H. Tao, A. Islam, K.J. Yu, T.I. Kim, R. Chowdhury, M. Ying, L. Xu, M. Li, H.J. Chung, H. Keum, M. McCormick, P. Liu, Y.W. Zhang, F.G. Omenetto, Y. Huang, T. Coleman, J.A. Rogers, Epidermal electronics, Science. 333 (2011).

DOI: 10.1126/science.1206157

[26] J.R. Windmiller, J. Wang, Wearable electrochemical sensors and biosensors: a review, Electroanalysis. 25 (2013) 29-46.

DOI: 10.1002/elan.201200349

[27] T. Guinovart, A.J. Bandodkar, J.R. Windmiller, F.J. Andrade, J. Wang, A potentiometric tattoo sensor for monitoring ammonium in sweat, Analyst. 138 (2013) 7031-7038.

DOI: 10.1039/c3an01672b

[28] A.J. Bandodkar, V.W. Hung, W. Jia, G. Valdés-Ramírez, J.R. Windmiller, A.G. Martinez, J. Ramírez, G. Chan, K. Kerman, J. Wang, Tattoo-based potentiometric ion-selective sensors for epidermal pH monitoring, Analyst. 138 (2013) 123-128.

DOI: 10.1039/c2an36422k

[29] A.J. Bandodkar, D. Molinnus, O. Mirza, T. Guinovart, J.R. Windmiller, G. Valdés-Ramírez, F.J. Andrade, M.J. Schöning, J. Wang, Epidermal tattoo potentiometric sodium sensors with wireless signal transduction for continuous non-invasive sweat monitoring, Biosensors and Bioelectronics. 54 (2014).

DOI: 10.1016/j.bios.2013.11.039

[30] W. Jia, A.J. Bandodkar, G. Valdes-Ramirez, J.R. Windmiller, Z. Yang, J. Ramirez, G. Chan, J. Wang, Electrochemical Tattoo Biosensors for Real-Time Noninvasive Lactate Monitoring in Human Perspiration, Anal. Chem. 85 (2013) 6553-6560.

DOI: 10.1021/ac401573r

[31] J.S. Mitchell, T.E. Lowe, J.R. Ingram, Rapid ultrasensitive measurement of salivary cortisol using nano-linker chemistry coupled with surface plasmon resonance detection, Analyst. 134 (2009) 380-386.

DOI: 10.1039/b817083p

[32] J.S. Mitchell, T.E. Lowe, Ultrasensitive detection of testosterone using conjugate linker technology in a nanoparticle-enhanced surface plasmon resonance biosensor, Biosensors and Bioelectronics. 24 (2009) 2177-2183.

DOI: 10.1016/j.bios.2008.11.018

[33] G. Saikia, P.K. Iyer, A remarkable superquenching and superdequenching sensor for the selective and noninvasive detection of inorganic phosphates in saliva, Macromolecules. 44 (2011) 3753-3758.

DOI: 10.1021/ma1026675

[34] M. Yamaguchi, M. Deguchi, J. Wakasugi, Flat-chip microanalytical enzyme sensor for salivary amylase activity, Biomed. Microdevices. 7 (2005) 295-300.

DOI: 10.1007/s10544-005-6071-1

[35] A.O. Aluoch, O.A. Sadik, G. Bedi, Development of an oral biosensor for salivary amylase using a monodispersed silver for signal amplification, Anal. Biochem. 340 (2005) 136-144.

DOI: 10.1016/j.ab.2005.02.003

[36] R.C. Kwan, H. Leung, P.Y. Hon, H.C. Cheung, K. Hirota, R. Renneberg, Amperometric biosensor for determining human salivary phosphate, Anal. Biochem. 343 (2005) 263-267.

DOI: 10.1016/j.ab.2005.05.021

[37] D. Du, J. Wang, J.N. Smith, C. Timchalk, Y. Lin, Biomonitoring of organophosphorus agent exposure by reactivation of cholinesterase enzyme based on carbon nanotube-enhanced flow-injection amperometric detection, Anal. Chem. 81 (2009) 9314-9320.

DOI: 10.1021/ac901673a

[38] C. Schabmueller, D. Loppow, G. Piechotta, B. Schütze, J. Albers, R. Hintsche, Micromachined sensor for lactate monitoring in saliva, Biosensors and Bioelectronics. 21 (2006) 1770-1776.

DOI: 10.1016/j.bios.2005.09.015

[39] A. Spehar‐Délèze, S. Anastasova, P. Vadgama, Electropolymerised Phenolic Films as Internal Barriers for Oxidase Enzyme Biosensors, Electroanalysis. (2013).

DOI: 10.1002/elan.201300371

[40] M.B. Lerner, N. Kybert, R. Mendoza, R. Villechenon, M.A.B. Lopez, A.C. Johnson, Scalable, non-invasive glucose sensor based on boronic acid functionalized carbon nanotube transistors, Appl. Phys. Lett. 102 (2013) 183113.

DOI: 10.1063/1.4804438

[41] J.H. Kim, P. McAuliffe, B. O'Connel, D. Diamond, K.T. Lau, Development of bite guard for wireless monitoring of bruxism using pressure-sensitive polymer, (2010) 109-116.

DOI: 10.1109/bsn.2010.62

[42] S. Ghimenti, T. Lomonaco, M. Onor, L. Murgia, A. Paolicchi, R. Fuoco, L. Ruocco, G. Pellegrini, M.G. Trivella, F. Di Francesco, Measurement of warfarin in the oral fluid of patients undergoing anticoagulant oral therapy, PloS one. 6 (2011).

DOI: 10.1371/journal.pone.0028182

[43] A. Millward, L. Shaw, E. Harrington, A. Smith, Continuous monitoring of salivary flow rate and pH at the surface of the dentition following consumption of acidic beverages, Caries Res. 31 (1997) 44-49.

DOI: 10.1159/000262373

[44] V.W. Yang, M. Wehbi, A. Peer, C. This, D.H. Dentists, Understanding Acid Reflux and Its Dental Manifestations, esophagus (Figure 4). 4 (2007) 5.

[45] C. Zuliani, G. Matzeu, D. Diamond, A potentiometric disposable sensor strip for measuring pH in saliva, Electrochim. Acta.

DOI: 10.1016/j.electacta.2014.03.140

[46] J. Wang, J. Kim, P. Mercier, A. Badodkar, J. Ramirez, A.G. Martinez, W. Jia, G.V. Ramirez, Non-invasive mouthguard biosensor for continuous salivary monitoring of metabolites, Analyst. (2014).

DOI: 10.1039/c3an02359a

[47] M.S. Mannoor, H. Tao, J.D. Clayton, A. Sengupta, D.L. Kaplan, R.R. Naik, N. Verma, F.G. Omenetto, M.C. McAlpine, Graphene-based wireless bacteria detection on tooth enamel, Nature communications. 3 (2012) 763.

DOI: 10.1038/ncomms1767