More than twenty years were needed for people to understand the formation mechanism of the periodic-layered structures not only because of the complications of pattern formation, but also due to the limits of traditional diffusion theories. Based on the general theory of interdiffusion growth proposed by Y.C. Chen et al. , the quantitative model of periodic layer formation during solid state reactions has been succeeded . The experimental results shown in this paper proved one of the model’s predicts that the reactive diffusion system Zn/Fe3Si with clamp press annealed at 663K should be mixed controlled. Also, the important influence of the uniaxial compressive stress on the diffusion coefficient was emphasized and the reasons are discussed.