Zirconia Biocompatibility in Animal Studies - A Systematic Review

Abstract:

Zirconia is a metal used in dental implantology. Its biocompatibility was studied in vitro and in vivo, results of the studies being analyzed in reviews and meta analyses. The aim of this systematic review was to evaluate biocompatibility of zirconia in animal studies in vivo expressed as results of histomorphometric tests. Databases were searched from 1980 until February 2016, with different combination of the following MeSH terms: zirconium, biocompatibility, dental implants, in vivo, animal studies. Letters to the editors, case reports, commentaries, review articles and articles published in other languages then English were excluded. The search of PubMed, ScienceDirect and Google Scholar databases yielded 690 titles. After abstract screening and duplicate discarding 50 articles were identified and finally, 40 were included in the review. Most of the studies compared zirconia with titanium, a well established material for dental implants. In majority of the studies zirconia showed a similar osseointegration with titanium. Surface implant treatments, like sandblasted and etched zirconia (ZrO2-SLA), alumina toughed zirconia (ATZ), and powder injection molding (PIM) were used to improve osseointegration of zirconia with good results. In the light of histomorphometric test, zirconia, no matter physical and structural forms tested, is a biocompatible material.

• Periodical: Defect and Diffusion Forum (Volume 376)
• Pages: 12-28
• DOI: https://doi.org/10.4028/www.scientific.net/DDF.376.12
• Online since: July 2017
• Authors: Sanda Mihaela Popescu, Horia Octavian Manolea*, Oana Andreea Diaconu, Rodica Mercuţ, Monica Scrieciu, Ionela Teodora Dascălu, Mihaela Jana Ţuculină, Florian Obădan, Florin Dan Popescu
• Keywords: Biocompatibility, Hard Tissues, In Vivo Animal Studies, Zirconia

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