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Evaluation of the Antibacterial Activity of Pinostrobin Derivative Compounds from Ethylation and Allylation Reactions

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Abstract:

Temu Kunci (Kaempferia pandurata Roxb.) is one of the plants from the Zingiberaceae family that contains secondary metabolites derived from flavonoids. Studies on the bioactivity of flavonoid compounds from this species have shown various biological activities such as antibacterial, antioxidant, antiviral, antitumor, antipyretic, anti-inflammatory, analgesic, and insecticidal properties. Pinostrobin (5-hydroxy-7-methoxy flavanone) (1) is the major flavonoid found in the rhizomes of this plant and has been successfully derivatized through ethylation and allylation reactions. Two compounds were obtained from the ethylation reaction, namely 5-ethoxy-7-methoxy flavanone (2) and 4'-ethoxy-6'-methoxy chalcone (3), while from the allylation reaction, 5-allyloxy-7-methoxy flavanone (4) and 6-allyl-7-methoxy flavanone (5) were obtained. Compounds 2, 3, 4, and 5 were tested for their antibacterial activity against the Gram-positive bacterium Staphylococcus aureus ATCC 25923 and the Gram-negative bacterium Escherichia coli ATCC 25922 using the agar diffusion method. The results of the inhibition zone measurements showed that compounds 2, 3, 4, and 5 were not active against S. aureus ATCC 25923 and E. coli ATCC 25922.

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Periodical:

Engineering Headway (Volume 14)

Pages:

63-68

DOI:

https://doi.org/10.4028/p-S3uCax

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Online since:

January 2025

Authors:

Soerya Dewi Marliyana*, Maulidan Firdaus, Muhamad Widyo Wartono, Diana Inas Utami, Uly Wulan Apriani

Keywords:

Antibacterial Activity, Ethylation and Allylation Reactions, Evaluation, Pinostrobin Derivative

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