For Libraries For Publication Open Access Downloads About Us Contact Us
Paper Titles
Porous PLGA Microspheres Effectively Loaded with BSA Protein by Electrospraying Combined with Phase Separation in Liquid Nitrogen
p.1
A Brief Review of the Modelling of the Time Dependent Mechanical Properties of Tissue Engineering Scaffolds
p.19
The Influence of Copolymer Compositions on the Physiochemical and Biological Properties of Poly (Lactic-co-Glycolic Acid) Porous Scaffolds
p.35
Designing Fail-Safe Biomaterials against Wear for Artificial Total Hip Replacement
p.45
The Application of Rapid Prototyping and Manufacturing for Anatomical Modelling in Medicine
p.57
Degradable Hydrogels for Tissue Engineering – Part I: Synthesis by RAFT Polymerization and Characterization of PHEMA Containing Enzymatically Degradable Crosslinks
p.67
Porous Alumina/Zirconia Composite Scaffold with Bioactive Glass 58S33C Coating
p.87

Porous Alumina/Zirconia Composite Scaffold with Bioactive Glass 58S33C Coating

Article Preview

Abstract:

Strong and tough, macroporous alumina/zirconia composites are superior to alumina scaffolds but still biologically inert to bone tissue, leading to poor tissue ingrowth and osteointegration. One way to solve this problem is applying a bioactive coating onto the pore walls of the macroporous composites. In this study, macroporous alumina/zirconia (20vol%) composites (scaffolds) were prepared by a vacuum infiltration method involving the use of strained (10%) compacts of the expanded polystyrene (EPS) beads (typically 1-2.8 mm in diameter). A bioactive glass (58S33C) coating (~ 20 μm) was applied on the pore walls of the macroporous composites by slurry dip coating and sintering at 1200 oC for 1 hour. A top or outer bioactive glass (58S33C) thin layer (< 10 μm) was further applied by sol dip coating and sintering at a low temperature (< 800 °C). The bioactive glass-coated macroporous alumina/zirconia composites had well interconnected pores, relatively large pore sizes (1-2 mm), medium porosities (60-66%), high compressive strengths (7.52 – 5.42 MPa), and high bioactivity (with an apatite layer formed within 24 hours in the simulated body fluid). The combination of the strong and ultrafine (if not nano-structured) macroporous scaffolds with the multiple or graded bioactive coatings represented a new generation of bone substitutes or permanent scaffolds for bone tissue regeneration.

You might also be interested in these eBooks
Journal of Biomimetics, Biomaterials and Tissue Engineering Vol.6 View Preview

Info:

Periodical:

Journal of Biomimetics, Biomaterials and Tissue Engineering (Volume 6)

Pages:

87-104

DOI:

https://doi.org/10.4028/www.scientific.net/JBBTE.6.87

Citation:

Cite this paper

Online since:

September 2010

Authors:

J. Liu, Z. Dong, X. Miao

Keywords:

Bioactive Glass, Dip-Coating, Porosity, Strength, Vacuum Infiltration (VI), Zirconia-Toughened Alumina (ZTA)

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

© 2010 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

References

[1] J. Wang, R. Stevens, J. Mater. Sci. 24 (1989) pp.2421-2440.

Google Scholar

[2] C. Kaya, E.G. Butler, Scripta Mater 48 (2004) pp.359-364.

Google Scholar

[3] A.S. Matthew, R.H. John, J. Am. Ceram. Soc. 12 (2002) pp.2895-2902.

Google Scholar

[4] M. Ruhle, N. Claussen, A.H. Heuer, J. Am. Ceram. Soc. 69.

Google Scholar

[3] (1986) pp.195-197.

Google Scholar

[5] L. Lefebvre, L. Gremillard, J. Chevalier, R. Zenati, D. Bernache-Assolant, Acta Biomaterialia 4 (2008) p.1894-(1903).

DOI: 10.1016/j.actbio.2008.05.019

Google Scholar

[6] O. Bretcanu, X. Chatzistavrou, K. Paraskevopoulos, R. Conradt, I. Thompson, A.R. Boccaccini, J. Eur. Ceram. Soc. 29.

Google Scholar

[2009] pp.3299-3306.

Google Scholar

[7] J. Zhong, D.C. Greenspan, J. Biomed. Mater. Res. (Appl. Biomater. ) 53 (2000) pp.694-701.

Google Scholar

[8] A. Rámila, M. Vallet-Regí, Biomaterials 22.

Google Scholar

[16] (2001) pp.2301-2306.

Google Scholar

[9] M. Takemoto, S. Fujibayashi, M. Neo, J. Suzuki, T. Kokubo, T. Nakamura, J. Biomed. Mater. Res. 78A (2006) pp.693-701.

DOI: 10.1002/jbm.a.30748

Google Scholar

[10] M. Hamadouche, A. Meunier, D.C. Greenspan, C. Blanchat, J.P. Zhong, G.P.L. Torre, L. Sedel, J. Biomed. Mater. Res. 52 (2000) pp.422-429.

DOI: 10.1002/1097-4636(200011)52:2<422::aid-jbm24>3.0.co;2-p

Google Scholar

[11] P. Torricelli, E. Verne, C.V. Brovarone, P. Appendino, F. Rustichelli, A. Krajewski, A. Ravaglioli, B. Pierini, M. Fini, G. Giavaresi, R. Giardino, Biomaterials 22 (2001) p.2535.

DOI: 10.1016/s0142-9612(00)00444-0

Google Scholar

[12] V. Stanic, N.N. Aldini, M. Fini, G. Giavaresi, R. Giardino, A. Krajewski, A. Ravaglioli, M. Mazzocchi, B. Dubini, M.G. Ponzi Bossi, F. Rustichelli, Biomaterials 23 (2002) pp.3833-3841.

DOI: 10.1016/s0142-9612(02)00119-9

Google Scholar

[13] M.H. Fathi, A. Doostmohammadi, Journal of materials processing technology. 209.

Google Scholar

[3] (2009) pp.1385-1391.

Google Scholar

[14] G. Jiang, D. Shi, Journal of Biomedical Materials Research Part B: Applied Biomaterials 43.

Google Scholar

[1] (1998) pp.77-81.

Google Scholar

[15] S. Bose, J. Darsell, H.L. Hosick, L.H. Yang, D.K. Sarkar, A. Bandyopadhyay, J. Mater. Sci. Mater. Med. 13 (2002) pp.23-28.

Google Scholar

[16] X. Miao, Y. Hu, J. Liu, X. Huang, Materials Science & Engineering C, Biomimetic and Supramolecular Systems 27.

Google Scholar

[2] (2007) pp.257-61.

Google Scholar

[17] X. Miao, International Conference on Frontiers in Materials Science & Technology (FMST2008) 2008 pp.211-14.

Google Scholar

[18] H.S. Costa, A.A.P. Mansur, E.F. Barbosa-Stancioli, M.M. Pereira, H.S. Mansur, Journal of Materials Science 43.

Google Scholar

[2] (2008) pp.510-24.

Google Scholar

[19] T. Takaoka, M. Okumura, H. Ohgushi, K. Inoue, Y. Yakakura, S. Tamai, Biomaterials 17.

Google Scholar

[15] (1996) pp.1499-1505.

Google Scholar

[20] C.C. Camilo, C.A. Fortulan, N.A. Parizotto, B. de M. Purquerio, Key Engineering Materials 396-398 (2009) pp.699-702.

DOI: 10.4028/www.scientific.net/kem.396-398.699

Google Scholar

[21] X. He, Y.Z. Zhang, J.P. Mansell, B. Su, J. Mater. Sci. Mater. Med. 19 (2008) pp.2743-2749.

Google Scholar

[22] J. Liu, X. Miao, Journal of Materials Science 40.

Google Scholar

[23] (2005) pp.6145-50.

Google Scholar

[23] T. Kokubo, H. Takadama, Biomaterials 27.

Google Scholar

[15] (2006) pp.2907-2915.

Google Scholar

[24] L. Radonjić, V. Srdić, Materials Chemistry and Physics 47.

Google Scholar

[1] (1997) pp.78-84.

Google Scholar

[25] F.F. Lange, T. Yamaguchi, B.I. Davis, P.E.D. Morgan, J. Am. Ceram. Soc. 71 (1988) p.446448.

Google Scholar

[26] F.F. Lange, M.M. Hirlinger, J. Am. Ceram. Soc. 67 (1984) pp.164-168.

Google Scholar

[27] E. Jallot, H. Benhayoune, L. Kilian, J.L. Irigaray, Y. Barbotteau, G. Balossier, P. Bonhomme, J. Coll. Inter. Sci. 283.

Google Scholar

[1] (2001) pp.83-90.

Google Scholar

[28] C.T. Wu, Y. Ramaswamy, Y.F. Zhu, R.K. Zheng, R. Appleyard, A. Howard, H. Zreiqat, Biomaterials 30 (2009) pp.2199-2208.

DOI: 10.1016/j.biomaterials.2009.01.029

Google Scholar

© 2025 Trans Tech Publications Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For open access content, terms of the Creative Commons licensing CC-BY are applied.
Scientific.Net is a registered trademark of Trans Tech Publications Ltd.