Screening of Nano-Drugs Dispersion of Imidazole Derivatives as Potential Anti-Cancer Agents

Abstract:

Imidazole is an aromatic and alkaloid diazole that shows prominent anticancer properties. Regulating the imidazole compound into nano-drugs in the size range 10-200 nm enhances the effectiveness of imidazole as an anti-cancer agent, thus enhancing therapeutic potential. In this study, imidazole nano drug dispersion was prepared using the re-precipitation method. The dispersion of various imidazole derivative compounds, namely 4-(4,5-diphenyl-1H-imidazol-2-yl)-2-methoxyphenol (Vanilin), 2-(4-Methoxyphenyl)-4,5-diphenyl-1H-imidazole (O-Me), 2,4,5-Triphenylimidazole (Benzaldehid) and 2-(4-nitrophenyl)-4,5-diphenyl-1H-imidazole (Nitro) were screened. The dispersion stability was evaluated in a mimic biological environment using phosphate buffer saline (PBS) for 24 hours, and the size of the nanodrugs was determined. The results showed that 4-(4,5-diphenyl-1H-imidazol-2-yl)-2-methoxyphenol had the best size of 203 nm, and no aggregation was observed even after 24h. This result indicates that 4-(4,5-diphenyl-1H-imidazol-2-yl)-2-methoxyphenol (Vanilin) meets the requirement of enhanced permeability retention (EPR) effect and is a prominent candidate as an effective anti-cancer agent.

• Periodical: Journal of Metastable and Nanocrystalline Materials (Volume 42)
• Pages: 57-66
• DOI: https://doi.org/10.4028/p-SQx6L6
• Online since: November 2025
• Authors: Amelia Bahetha, Kharisma Amalia Septia Putri, Harmami Harmami, Ita Ulfin, Firman Shantya Budi, Arif Fadlan, Mohd Hafidzal Mohd Hanafi, Muh. Nur Khoiru Wihadi, Grasianto Grasianto*
• Keywords: Anticancer, Coating, Dispersion, Imidazole, Nanodrugs

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