Visible Light Triggered Chlorhexidine Release of Nitrogen-Doped TiO₂ Nanoparticle Dental Desensitizer

Abstract:

The purpose of this study was to develop a novel dental desensitizer with nitrogen-doped TiO₂ nanoparticles that show an optical response under visible light and investigate the triggered release of chlorhexidine from these nanoparticles in response to remote visible-light irradiation. Diffusive ultraviolet-visible spectroscopy indicated that N-doped TiO₂ nanoparticles solvothermally treated at 130°C for 2 h showed the highest absorbance at 470 nm. X-ray photoelectron spectroscopy confirmed that nitrogen was substantially doped into the TiO₂ lattice via the existence of N–Ti–O or N–Ti–N linkages (396.1 eV of N 1s). Chlorhexidine-release and agar-diffusion antibacterial tests revealed that visible-light irradiation statistically accelerated the chlorhexidine release and antibacterial activity. An agar overlay biocompatibility test showed that only the 0.1% chlorhexidine experimental group was biocompatible according to ISO 7405. Therefore, N-doped TiO₂ nanoparticles should enable the development of new visible-light-mediated antibacterial desensitizers in the field of dentistry.

• Periodical: Journal of Nano Research (Volume 43)
• Pages: 57-62
• DOI: https://doi.org/10.4028/www.scientific.net/JNanoR.43.57
• Online since: September 2016
• Authors: Ji Young Park, Kyung Sook Moon, Soo Ha Jeong, Jeong Mi Kim, Seung Han Oh*
• Keywords: Antibacterial Activity, Biocompatibility, Chlorhexidine, Dental Desensitizer, Nitrogen-Doped TiO₂ Nanoparticle, Visible Light Triggered Release

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