An Al2O3 matrix composites, i.e. partially stabilized zirconia toughening alumina (ZTA) reinforced by SiC particle (ZTA-SiCP), was prepared by hot pressing (HP). Fatigue behavior of ZTA-SiCP under cyclic compressive loads was investigated on different loading conditions. The application of cyclic compressive loads to a notched specimen led to a stable crack growth along the notch plane in a direction normal to the far-field compressive axis. Irreversible damages in the main form of microcrack were induced at the stress concentration zone during compression loading, and it led to high residual tensile stresses ahead of the notch root upon unloading. Nucleation and growth of a model I fatigue crack were caused by the residual tensile stresses at the notch root. Along with propagation of the fatigue crack, a gradual decrease in crack growth rate was shown due to the crack closure caused by accumulating of debris particles within the wake of growing crack, and thus led to the crack arrested at last. The fatigue crack length was investigated as a function of notch length, the maximum compressive stress, stress range and load frequency.