Bisphosphonates Incorporated on a Ca-P Biomimetic Coating Produced by a Sodium Silicate Based Methodology Stimulate Osteoblastic Activity

Abstract:

In the present study sodium clodronate, a well known therapeutic agent from the family of bisphosphonates (BP) was incorporated in an apatite coating, previously formed on the surface of a starch based biomaterial by a sodium silicate methodology, as a strategy to develop a site-specific drug delivery system for bone tissue regeneration. The effects on the resulting apatite coatings were evaluated in terms of morphology, chemistry and structure. As a preliminary approach, this first study aimed at evaluating also the effects of this BP on the viability, growth and function of a human osteoblast cell line, since there is still little information available on the interaction between BPs and this type of cells.

• Periodical: Key Engineering Materials (Volumes 284-286)
• Pages: 615-618
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.284-286.615
• Online since: April 2005
• Authors: A.L. Oliveira, M.I. Santos, A.A. Pedro, Rui L. Reis
• Keywords: Biodegradable Polymer, Biomimetic Coating, Bisphosphonate, Calcium Phosphate, Drug Therapy, Sodium Silicate, Starch

References

[1] G. A. Rodan and T. J. Martin: Science (2000), 1508-1514.

[2] G. A. Rodan and H. A. Fleisch: Journal of Clinical Investigation (1996), 2692-2696.

[3] H. Fleisch: Expert Opinion on Therapeutic Patents (2001), 1371-1381.

[4] A. Ezra and G. Golomb: Adv Drug Deliv Rev (2000), 175-95.

[5] A. L. Oliveira, P. B. Malafaya and R. L. Reis: Biomaterials (2003), 2575-2584.

[6] A. L. Oliveira, C. M. Alves and R. L. Reis: Journal of Materials Science-Materials in Medicine (2002), 1181-1188.

[7] R. L. Reis, A. M. Cunha, M. H. Fernandes and R. N. Correia: Journal of Materials ScienceMaterials in Medicine (1997), 897-905.

[8] A. L. Oliveira, Elvira, C., Vásquez, B., San Roman, J., Reis, R. L.: Journal of Materials Science: Materials in Medicine (1999), 827.

[9] T. Kokubo, H. M. Kim, M. Kawashita and T. Nakamura: Z Kardiol (2001), 86-91.

[10] A. L. Oliveira and R. L. Reis: Journal of Materials Science: Materials in Medicine (2004), 533- 540.

[11] R. L. Reis and A. M. Cunha: Journal of Materials Science-Materials in Medicine (1995), 786- 792.

[12] M. E. Gomes, J. S. Godinho, D. Tchalamov, A. M. Cunha and R. L. Reis: Materials Science & Engineering C-Biomimetic and Supramolecular Systems (2002), 19-26.

[13] C. Elvira, J. F. Mano, J. San Roman and R. L. Reis: Biomaterials (2002), 1955-66.