In Situ Monitoring of Chondrocyte Response to Bioactive Scaffolds Using Raman Spectroscopy

Abstract:

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Septal cartilage is widely used for the repair of soft tissue defects in the head, neck and nose. Tissue Engineering techniques are being investigated to create cartilage in vitro by seeding appropriate cells on resorbable scaffolds. In this study, human chondrocytes were cultured on macroporous bioactive glass foam scaffolds. The aim was to investigate how Raman spectroscopy could be used as a non-invasive technique to monitor the response of chondrocytes to a 3D scaffold in real time. The spectra were compared to scanning electron microscope (SEM) micrographs and immunohistochemistry results.

Info:

Periodical:

Key Engineering Materials (Volumes 284-286)

Main Theme:

Edited by:

Panjian Li, Kai Zhang and Clifford W. Colwell, Jr.

Pages:

623-626

DOI:

10.4028/www.scientific.net/KEM.284-286.623

Citation:

J. R. Jones et al., "In Situ Monitoring of Chondrocyte Response to Bioactive Scaffolds Using Raman Spectroscopy ", Key Engineering Materials, Vols. 284-286, pp. 623-626, 2005

Online since:

April 2005

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Price:

$35.00

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