Effects of Cyclic RGD Peptide Functionalization on the Quantitative Bone Ingrowth Process in Cellularized Biphasic Calcium Phosphate Ceramics

Abstract:

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The aim of this study was to evaluate the in vivo effects of the grafting of cyclo- DfKRG on the early phase of integration of biomaterials made with macroporous hydroxyapatite/b-tricalcium phosphate colonized with autologous bone marrow stromal cells. Non-grafted (-RGD) and grafted (+RGD) biomaterials were implanted in both femoral condyles of rabbits for 2 and 4 weeks. Two weeks after implantation, the global bone formation was higher with +RGD samples (p=0.02). There remained no significant difference 4 weeks after implantation. In conclusion, grafting of cyclo-DfKRG peptide on materials could promote cell colonization and improve osteoconduction during the first stage of the bone cicatrization process.

Info:

Periodical:

Key Engineering Materials (Volumes 284-286)

Main Theme:

Edited by:

Panjian Li, Kai Zhang and Clifford W. Colwell, Jr.

Pages:

647-650

DOI:

10.4028/www.scientific.net/KEM.284-286.647

Citation:

J. C. Fricain et al., "Effects of Cyclic RGD Peptide Functionalization on the Quantitative Bone Ingrowth Process in Cellularized Biphasic Calcium Phosphate Ceramics ", Key Engineering Materials, Vols. 284-286, pp. 647-650, 2005

Online since:

April 2005

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Price:

$35.00

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