Effects of Cyclic RGD Peptide Functionalization on the Quantitative Bone Ingrowth Process in Cellularized Biphasic Calcium Phosphate Ceramics

Jean Christophe Fricain; L. Pothuaud; M.C. Durrieu; S. Pallu; Reiner Bareille; M. Renard; J. Jeanfils; M. Dard; J. Amédée

doi:10.4028/www.scientific.net/KEM.284-286.647

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HomeKey Engineering MaterialsKey Engineering Materials Vols. 284-286Effects of Cyclic RGD Peptide Functionalization on...

Effects of Cyclic RGD Peptide Functionalization on the Quantitative Bone Ingrowth Process in Cellularized Biphasic Calcium Phosphate Ceramics

Abstract:

The aim of this study was to evaluate the in vivo effects of the grafting of cyclo- DfKRG on the early phase of integration of biomaterials made with macroporous hydroxyapatite/b-tricalcium phosphate colonized with autologous bone marrow stromal cells. Non-grafted (-RGD) and grafted (+RGD) biomaterials were implanted in both femoral condyles of rabbits for 2 and 4 weeks. Two weeks after implantation, the global bone formation was higher with +RGD samples (p=0.02). There remained no significant difference 4 weeks after implantation. In conclusion, grafting of cyclo-DfKRG peptide on materials could promote cell colonization and improve osteoconduction during the first stage of the bone cicatrization process.

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Key Engineering Materials (Volumes 284-286)

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647-650

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.284-286.647

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April 2005

Authors:

Jean Christophe Fricain, L. Pothuaud, M.C. Durrieu, S. Pallu, Reiner Bareille, M. Renard, J. Jeanfils, M. Dard, J. Amédée

Keywords:

Bone Tissue Engineering, Histomorphometry, Image Analysis, RGD Peptide

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References

[1] K. Kurashina, H. Kurita, Q. Wu, A. Ohtsuka, H. Kobayashi : Biomaterials Vol. 23 (2002), p.407.

Google Scholar

[2] N. Passuti, G. Dacusli, J.M. Rogez, S. Martin, J.V. Bainvel : Clin Orthop, Vol. 248 (1989), p.169.

Google Scholar

[3] J.S. Boo, Y. Yamada, Y. Okazaki, Y. Hibino, K. Okada, K. Hata, T. Yoshikawa, Y. Sugiura, M. Ueda : J Craniofac Surg Vol. 13 (2002), p.231.

DOI: 10.1097/00001665-200203000-00009

Google Scholar

[4] J.W. Vehof, P.H. Spauwen, J.A. Jansen : Biomaterials Vol. 21 (2000), p. (2003).

Google Scholar

[5] S. Pallu, R. Bareille, M. Dard, H. Kessler, A. Jonczyk, M. Vernizeau, J. Amédée-Vilamitjana : Peptides, Vol. 24 (2003), p.1349.

DOI: 10.1016/j.peptides.2003.09.003

Google Scholar

[6] E. Wolf : Virchow Archiv. Pathol. Anat. Histopathol. Vol. 420 (1992), p.17.

Google Scholar

[7] D.M. Ferris, G.D. Moodie, P.M. Dimond, C.W. Gioranni, M.G. Ehrlich, R.F. Valentini : Biomaterials Vol. 20 (1999), p.2323.

Google Scholar

[8] H. Schliephake, D. Scharnweber, M. Dard, S. Rossler, A. Sewing, J. Meyer, D. Hoogestraat : Clin. Oral Implants Res. Vol. 13 (2002), p.312.

DOI: 10.1034/j.1600-0501.2002.130312.x

Google Scholar

[9] K. Ohura, M. Bohner, P. Hardouin, J. Lemaitre, G. Pasquier, B. Flautre : J. Biomed. Mater. Res. Vol. 30 (1996), 193.

DOI: 10.1002/(sici)1097-4636(199602)30:2<193::aid-jbm9>3.0.co;2-m

Google Scholar

[10] A. Piattelli, A. Scarano, M. Quaranta : Biomaterials Vol. 18 (1997), p.1191.

Google Scholar

[11] G. Daculsi, N. Passuti, S. Martin, C. Deudon, R.Z. Legeros, S. Raher : J. Biomed. Mater. Res. Vol. 24, (1990), p.379.

DOI: 10.1002/jbm.820240309

Google Scholar