In Vitro Culture of Osteoblasts with Three Dimensionally Ordered Macroporous Sol-Gel Bioactive Glass (3DOM-BG) Particles
Three dimensionally ordered macroporous sol-gel bioactive glasses (3DOM-BGs)are a type of biomaterial that is both bioactive and resorbable. In this study, 80 % SiO2 – 20 % CaO (molar fraction) 3DOM-BG particles were prepared using a colloidal crystal templating method via a sol-gel process. The as-prepared 3DOM-BG particles can quickly convert to a calcium-deficient, bone-like apatite after soaking in a simulated body fluid (SBF). MC3T3-E1 osteoblastic cells were cultured in the presence of 3DOM-BG particles. Preliminary results from cell studies showed that 3DOM-BG particles are not cytotoxic and are compatible with MC3T3-E1 osteoblast-like cells in vitro.
Panjian Li, Kai Zhang and Clifford W. Colwell, Jr.
K. Zhang et al., "In Vitro Culture of Osteoblasts with Three Dimensionally Ordered Macroporous Sol-Gel Bioactive Glass (3DOM-BG) Particles ", Key Engineering Materials, Vols. 284-286, pp. 655-658, 2005