In Vitro Culture of Osteoblasts with Three Dimensionally Ordered Macroporous Sol-Gel Bioactive Glass (3DOM-BG) Particles

Kai Zhang; Newell R. Washburn; Joseph M. Antonucci; Carl G. Simon

doi:10.4028/www.scientific.net/KEM.284-286.655

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In Vitro Culture of Osteoblasts with Three Dimensionally Ordered Macroporous Sol-Gel Bioactive Glass (3DOM-BG) Particles
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HomeKey Engineering MaterialsKey Engineering Materials Vols. 284-286In Vitro Culture of Osteoblasts with Three...

In Vitro Culture of Osteoblasts with Three Dimensionally Ordered Macroporous Sol-Gel Bioactive Glass (3DOM-BG) Particles

Abstract:

Three dimensionally ordered macroporous sol-gel bioactive glasses (3DOM-BGs)are a type of biomaterial that is both bioactive and resorbable. In this study, 80 % SiO2 – 20 % CaO (molar fraction) 3DOM-BG particles were prepared using a colloidal crystal templating method via a sol-gel process. The as-prepared 3DOM-BG particles can quickly convert to a calcium-deficient, bone-like apatite after soaking in a simulated body fluid (SBF). MC3T3-E1 osteoblastic cells were cultured in the presence of 3DOM-BG particles. Preliminary results from cell studies showed that 3DOM-BG particles are not cytotoxic and are compatible with MC3T3-E1 osteoblast-like cells in vitro.

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Key Engineering Materials (Volumes 284-286)

Pages:

655-658

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.284-286.655

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Online since:

April 2005

Authors:

Kai Zhang, Newell R. Washburn, Joseph M. Antonucci, Carl G. Simon

Keywords:

Apatite, Bioactive Glass, Biocompatibility, Cytotoxicity, In Vitro, Osteoblast, Sol-Gel (SG)

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