In Vitro Culture of Osteoblasts with Three Dimensionally Ordered Macroporous Sol-Gel Bioactive Glass (3DOM-BG) Particles

Abstract:

Article Preview

Three dimensionally ordered macroporous sol-gel bioactive glasses (3DOM-BGs)are a type of biomaterial that is both bioactive and resorbable. In this study, 80 % SiO2 – 20 % CaO (molar fraction) 3DOM-BG particles were prepared using a colloidal crystal templating method via a sol-gel process. The as-prepared 3DOM-BG particles can quickly convert to a calcium-deficient, bone-like apatite after soaking in a simulated body fluid (SBF). MC3T3-E1 osteoblastic cells were cultured in the presence of 3DOM-BG particles. Preliminary results from cell studies showed that 3DOM-BG particles are not cytotoxic and are compatible with MC3T3-E1 osteoblast-like cells in vitro.

Info:

Periodical:

Key Engineering Materials (Volumes 284-286)

Main Theme:

Edited by:

Panjian Li, Kai Zhang and Clifford W. Colwell, Jr.

Pages:

655-658

Citation:

K. Zhang et al., "In Vitro Culture of Osteoblasts with Three Dimensionally Ordered Macroporous Sol-Gel Bioactive Glass (3DOM-BG) Particles ", Key Engineering Materials, Vols. 284-286, pp. 655-658, 2005

Online since:

April 2005

Export:

Price:

$38.00

[1] Hench L.L. and Polak JM, Science, Vol. 295 (2002), p.1014.

[2] Wheeler D. L., Eschbach E. J., Hoellrich R. G., Montfort M. J., Chamberland D. L., J Orthopaedic Res Vol. 18 (2000), p.140.

[3] Hamadouche M., Meunier A., Greenspan D. C., Blanchat C., Zhong J. P., La Torre G. P., Sedel L., J Biomed Mater Res Vol. 54 (2001), p.560.

DOI: https://doi.org/10.1002/1097-4636(20010315)54:4<560::aid-jbm130>3.3.co;2-a

[4] Li P., Nakanishi K., Kokubo T., De Groot K., Biomaterials, Vol. 14 (1993), p.963.

[5] Pereira M. M., Clark A. E., Hench L. L., J Am Ceram Soc Vol. 78 (1995), p.2463.

[6] Perez-Pariente J., Balas F., Roman J., Salinas A. J., Vallet-Regi M., J Biomed Mater Res Vol. 47 (1999), p.170.

[7] Sepulveda P., Jones J. R., Hench L. L., J Biomed Mater Res Vol. 59 (2002), p.340.

[8] Yan H., Zhang K., Blanford C.F., Francis L. F., Stein A., Chem. Mater., Vol. 13 (2001), p.1374.

[9] Zhang K., Yan H., Bell D. C., Stein A., Francis L. F., J. Biomed. Mater. Res., Vol. 66A (2003), p.860.

[10] Zhang K., Yan H., Stein A., Francis L. F., J. Am. Ceram. Soc., in press.

[11] Stein A, Schroden RC, Current Opinion in Solid State & Materials Sci., Vol. 5 (2001), p.553.

[12] Simon C. G., Khatri C. A., Wight S. A., Wang F. W., J Orthopaedic Res., Vol. 20 (2002), p.473.

[13] Loty C., Sautier JM, Tan MT, Oboeuf M, Jallot E., Boulekbache H., Greenspan D., Forest N., J. Bone. Miner. Res., Vol. 16 (2001).

DOI: https://doi.org/10.1359/jbmr.2001.16.2.231