Blood Compatibility of Organic-Inorganic Biomedical Materials
Organic-inorganic hybrids involving Ti-O bonds were coated on stainless-steel (SUS316L)substrates. Tetraisopropoxide and titanium methacrylate triisopropoxide were employed as the major starting chemicals to provide TiO2-polydimethylsiloxane (PDMS) layers or organotitanium molecular thin layers, respectively. Fourier transform infrared spectra indicated that each layer contained Ti-O bonds in their structure. The obtained hybrid layers had little effects on the blood-clotting times such as active partial thromboplastin time and prothrombin time. In addition, the number of adhered platelet on the TiO2-PDMS layers depended on the composition, while the organotitanium molecular thin layers suppressed fibrinogen adsorption compared with coating-free SUS 316L substrate.
Panjian Li, Kai Zhang and Clifford W. Colwell, Jr.
A. Osaka et al., "Blood Compatibility of Organic-Inorganic Biomedical Materials ", Key Engineering Materials, Vols. 284-286, pp. 713-716, 2005