Blood Compatibility of Organic-Inorganic Biomedical Materials

Abstract:

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Organic-inorganic hybrids involving Ti-O bonds were coated on stainless-steel (SUS316L)substrates. Tetraisopropoxide and titanium methacrylate triisopropoxide were employed as the major starting chemicals to provide TiO2-polydimethylsiloxane (PDMS) layers or organotitanium molecular thin layers, respectively. Fourier transform infrared spectra indicated that each layer contained Ti-O bonds in their structure. The obtained hybrid layers had little effects on the blood-clotting times such as active partial thromboplastin time and prothrombin time. In addition, the number of adhered platelet on the TiO2-PDMS layers depended on the composition, while the organotitanium molecular thin layers suppressed fibrinogen adsorption compared with coating-free SUS 316L substrate.

Info:

Periodical:

Key Engineering Materials (Volumes 284-286)

Main Theme:

Edited by:

Panjian Li, Kai Zhang and Clifford W. Colwell, Jr.

Pages:

713-716

DOI:

10.4028/www.scientific.net/KEM.284-286.713

Citation:

A. Osaka et al., "Blood Compatibility of Organic-Inorganic Biomedical Materials ", Key Engineering Materials, Vols. 284-286, pp. 713-716, 2005

Online since:

April 2005

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Price:

$35.00

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