Blood Compatibility of Organic-Inorganic Biomedical Materials

Akiyoshi Osaka; Tomohiko Yoshioka; Takeshi Yabuta; Kanji Tsuru; Satoshi Hayakawa

doi:10.4028/www.scientific.net/KEM.284-286.713

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HomeKey Engineering MaterialsKey Engineering Materials Vols. 284-286Blood Compatibility of Organic-Inorganic...

Blood Compatibility of Organic-Inorganic Biomedical Materials

Abstract:

Organic-inorganic hybrids involving Ti-O bonds were coated on stainless-steel (SUS316L)substrates. Tetraisopropoxide and titanium methacrylate triisopropoxide were employed as the major starting chemicals to provide TiO2-polydimethylsiloxane (PDMS) layers or organotitanium molecular thin layers, respectively. Fourier transform infrared spectra indicated that each layer contained Ti-O bonds in their structure. The obtained hybrid layers had little effects on the blood-clotting times such as active partial thromboplastin time and prothrombin time. In addition, the number of adhered platelet on the TiO2-PDMS layers depended on the composition, while the organotitanium molecular thin layers suppressed fibrinogen adsorption compared with coating-free SUS 316L substrate.

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Key Engineering Materials (Volumes 284-286)

Pages:

713-716

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.284-286.713

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Online since:

April 2005

Authors:

Akiyoshi Osaka, Tomohiko Yoshioka, Takeshi Yabuta, Kanji Tsuru, Satoshi Hayakawa

Keywords:

Blood Compatibility, Organic-Inorganic Hybrid, Titanium Oxide

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