A New Cellular Model for In Vitro Biocompatibility Evaluation of Microcapsule Materials

Hua'an Zhang; Lin Sun; Wei Wang; Xiao Jun Ma

doi:10.4028/www.scientific.net/KEM.288-289.499

Paper Titles

The Influence of Different Base Materials on Marginal Adaptation of Direct Class II Composite Resin Restorations
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Synthesis and Biocompatibility Evaluation of Poly(HEMA-Co-MMA) Orbital Implant
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Temporal and Spatial Expression Pattern of VEGF and VEGF Receptor in the Posterior Spinal Fusion with Allograft
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New Method for Evaluating Material Blood Compatibility Using Microchannel Array
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A New Cellular Model for In Vitro Biocompatibility Evaluation of Microcapsule Materials
p.499

Computer-Assisted Image Processing Techniques for Quantitative Analysis of Cell Migrations on Collagen-Coated Glass
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Cytokine Expression of Cultured Human Endothelial Cells Exposed to Biomaterials
p.507

A Novel Method for Evaluating Compatibility of Hepatocytes with some Kinds of Biomaterials
p.511

Research on Platelet Adsorption Behavior Using Enzyme Immunoassays and LDH Testing
p.515

HomeKey Engineering MaterialsKey Engineering Materials Vols. 288-289A New Cellular Model for In Vitro Biocompatibility...

A New Cellular Model for In Vitro Biocompatibility Evaluation of Microcapsule Materials

Abstract:

Fibrosis caused by the host response to long-term transplanted microcapsules and the limitation of traditional L929 cell model for biocompatibility testing inspire the development of an assay of biocompatibility based on macrophage behavior. In this paper, the human monocytic cell line THP-1 was utilized for biocompatibility evaluation of microcapsule materials. The cell viability and secretion of nitric oxide (NO) and cytokines served as index of biocompatibility were assayed. It was found that the evaluated microcapsule materials had no effect on the stimulation of NO and cytokines secretion, which meant that these materials were biocompatible. Furthermore, it suggests the THP-1 cell a convenient in vitro experimental model that might be useful for long-term predictions of material biocompatibility.

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Key Engineering Materials (Volumes 288-289)

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499-502

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https://doi.org/10.4028/www.scientific.net/KEM.288-289.499

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Online since:

June 2005

Authors:

Hua'an Zhang, Lin Sun, Wei Wang, Xiao Jun Ma

Keywords:

Alginate, Biocompatibility, Chitosan (CS), In Vitro

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