Zr-4 alloy is the material of nuclear fuel shell in nuclear power plant’s PWR. This paper presents this material’s general mechanical property and fatigue behavior that are tested in accordance with ASTM in room temperature and 380°C condition. The test results show that there is no cyclic hardening or cyclic softening phenomena for Zr-4 alloy applied by cyclic loading in room temperature condition. The fatigue design curve is obtained by processing fatigue test results with adopting ASME Sec.Ⅲ based on the test results of strain fatigue property. The research result shows the fatigue design data at different temperature may be corrected by elastic modulus with room temperature curve. This paper’s result may be used in PWR component design.