Performance of Osteoinductive Biphasic Calcium-Phosphate Ceramic in a Critical-sized Defect in Goats

Pamela Habibovic; Mirella van den Doel; Clemens A. van Blitterswijk; K. de Groot

doi:10.4028/www.scientific.net/KEM.309-311.1303

Paper Titles

Zirconia Knee Wear and Raman Spectroscopy Studies Compares 3.5-Mrad and 7-Mrad UHMWPE Inserts
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Improvements of Wear Properties DLC Coated UHMWPE and PMMA for Biomaterial
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Enhancement of Differentiation and Homeostasis of Human Osteoblasts by Interaction with Hydroxyapatite in Microsphere Form
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Surface Characteristics and Osteoinductivity of Biphasic Calcium Phosphate Ceramics with Different Sintering Temperature
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Performance of Osteoinductive Biphasic Calcium-Phosphate Ceramic in a Critical-sized Defect in Goats
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Influence of Physico-Chemical Properties, Macro- and Microstructure on Osteoinductive Potential of Calcium-Phosphate Ceramics
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In Vivo Evaluation of Porous Hydroxyapatite/Poly D/L-lactide Composite for Bone Substitutes and Scaffolds
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Enhanced Osteoinductivity of Porous Titanium Implant by Sodium Removal
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Safety of Ceramic Components
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Performance of Osteoinductive Biphasic Calcium-Phosphate Ceramic in a Critical-sized Defect in Goats

Abstract:

Osteoinductive biomaterials are able of inducing bone formation at ectopic, i.e. extraskeletal implantation sites. It is, however, important to investigate whether osteoinductive biomaterials perform better when implanted orthotopically as well, in particular in clinically relevant criticalsized defects. In this study, an osteoinductive and a non-osteoinductive biphasic calcium-phosphate (BCP) ceramic were compared in a critical-sized iliac wing defect that allows for paired comparison. After 12 weeks of implantation in the critical-sized defect, the osteoinductive BCP1150 ceramic showed significantly more bone than the non-osteoinductive BCP1300 ceramic. In addition, the analysis of fluorochrome markers, which were administered to the animals 4, 6 and 8 weeks after implantation in order to visualize the bone growth dynamics, showed an earlier start of bone formation in BCP1150 as compared to BCP1300. Significantly better performance of osteoinductive ceramic in a critical-sized orthotopic defect in a large animal model in comparison to the non-osteoinductive ceramic suggests osteoinduction to be clinically relevant.