Immediate Mechanism of the Osteoconductivity of the Polarized Hydroxyapatite
We investigated the immediate response in the vicinity of the implanted polarized hydroxyapatite (HA). One of the important immediate events was found to be the fibrin adsorption on the implanted HA. The activation of the fibrin adsorption on the polarized HA was confirmed by the observation by SEM observation and immunohistochemical detection. After the implantation, the coagulation cascade induced the wound healing. The adsorbed fibrin was formed network structure and worked for later cell responses as the scaffolds. The acceleration of fibrin scaffolds formation in the vicinity of the implanted polarized HA contributed to the stimulation and activation of plate ets and osseous cells. The platelets were activated from the results of the signal transduction and cytoskeleton changes and released growth factors. The growth factors released from platelets led to bone regeneration by stimulating migration and proliferation of the osseous cells. In the vicinity of the implanted HA samples, the coagulation cascade reaction to repair wound healing led to the new bone formation by mediation of the platelets and osseous cells. The mechanism of osteoconduction at earlier stage had close relationships to the electrostatic properties of the implant.
Takashi Nakamura, Kimihiro Yamashita and Masashi Neo
M. Nakamura et al., "Immediate Mechanism of the Osteoconductivity of the Polarized Hydroxyapatite ", Key Engineering Materials, Vols. 309-311, pp. 1413-0, 2006