TiO2-HDPE Composite: Bone Bonding Ability and Biocompatibility
A novel material, namely, TiO2-HDPE (TiO2/high density polyethylene) composite was developed by our research group. Its mechanical properties are similar to those of the human cortical bone; hence, we examined the possibility of using it as a bone substitute. We prepared two groups of TiO2-HDPE; one was subjected to ultraviolet irradiation for 0.1 h and the other for 9 h. In bone bonding ability test, the former indicated a lower ability than the latter, which showed approximately 7 to 8 N of failure load. The bone bonding ability of the latter group alone is not sufficient for clinical application; on the other hand, the biocompatibility test was carried out. In the biocompatibility test, the group that was irradiated for 9 h revealed neither a major inflammatory response nor formation of neoplasm. We have to further examine alternate types of polyethylene or TiO2 particles in order to improve the bone bonding ability.
Takashi Nakamura, Kimihiro Yamashita and Masashi Neo
T. Nasu et al., "TiO2-HDPE Composite: Bone Bonding Ability and Biocompatibility ", Key Engineering Materials, Vols. 309-311, pp. 415-418, 2006