Preparation of Hollow Y2O3 Microspheres for In Situ Radiotherapy of Cancer by Enzymatic Reaction
Chemically durable microspheres 20−30 µm in diameter containing a large amount of yttrium are useful for in situ radiotherapy of cancer as they can be activated by neutron bombardment to become β-emitters and can be injected in the vicinity of the cancer to provide a large localized dose of β-radiation. In this study, preparation of hollow Y2O3 microspheres using an enzymatic reaction was attempted, and the structure and chemical durability of the resulting microspheres were investigated. Hollow Y2O3 microspheres 20–30 &m in diameter were successfully prepared by this enzymatic method. The outer surface of the microspheres was smooth and dense, whereas the inner parts had a honeycombed structure. In simulated body fluids at pH 6 and 7, the hollow Y2O3 microspheres showed high chemical durability.
Takashi Nakamura, Kimihiro Yamashita and Masashi Neo
K. Masakazu et al., "Preparation of Hollow Y2O3 Microspheres for In Situ Radiotherapy of Cancer by Enzymatic Reaction", Key Engineering Materials, Vols. 309-311, pp. 461-464, 2006