Preparation of Hollow Y2O3 Microspheres for In Situ Radiotherapy of Cancer by Enzymatic Reaction

Abstract:

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Chemically durable microspheres 20−30 µm in diameter containing a large amount of yttrium are useful for in situ radiotherapy of cancer as they can be activated by neutron bombardment to become β-emitters and can be injected in the vicinity of the cancer to provide a large localized dose of β-radiation. In this study, preparation of hollow Y2O3 microspheres using an enzymatic reaction was attempted, and the structure and chemical durability of the resulting microspheres were investigated. Hollow Y2O3 microspheres 20–30 &m in diameter were successfully prepared by this enzymatic method. The outer surface of the microspheres was smooth and dense, whereas the inner parts had a honeycombed structure. In simulated body fluids at pH 6 and 7, the hollow Y2O3 microspheres showed high chemical durability.

Info:

Periodical:

Key Engineering Materials (Volumes 309-311)

Main Theme:

Edited by:

Takashi Nakamura, Kimihiro Yamashita and Masashi Neo

Pages:

461-464

DOI:

10.4028/www.scientific.net/KEM.309-311.461

Citation:

K. Masakazu et al., "Preparation of Hollow Y2O3 Microspheres for In Situ Radiotherapy of Cancer by Enzymatic Reaction", Key Engineering Materials, Vols. 309-311, pp. 461-464, 2006

Online since:

May 2006

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Price:

$35.00

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