Preparation of Silica-Doped Poly(Lactic Acid) Composite Hollow Spheres Containing Calcium Carbonates

Noriko Miura; Hirotaka Maeda; Toshihiro Kasuga

doi:10.4028/www.scientific.net/KEM.309-311.457

Paper Titles

Direct Gel-Casting of Zirconia for Dental Application: Gelation Kinetics and Pyrolysis of Organic Additives
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Apatite Formation on Zirconia Based Composites
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Biocompatibility of the Outer Prismatic and the Inner Nacreous Layers of Four Different Molluscs
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In Vitro Bioactivity Assessment of Metallic Magnesium
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Preparation of Silica-Doped Poly(Lactic Acid) Composite Hollow Spheres Containing Calcium Carbonates
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Preparation of Hollow Y₂O₃ Microspheres for In Situ Radiotherapy of Cancer by Enzymatic Reaction
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Bioactive Non-Woven Silica Fabric Made Through Electro-Spinning Method
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Osteoblast-Like Cell Behaviors on Non-Woven Silica Fabric
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An Economic Method for Chitosan Production
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Preparation of Silica-Doped Poly(Lactic Acid) Composite Hollow Spheres Containing Calcium Carbonates

Abstract:

Silica-doped poly(lactic acid) (PLA) composite hollow spheres containing calcium carbonates (Si-CCPC spheres) were prepared using aminopropyltriethoxysilane (APTES) for injectable bone fillers combined with a cell-delivery system. Si-CCPC spheres have a hollow spherical shape of ~1 mm in the external diameter and an open channel in the shell, which is selfformed. The channel size is about 500 *m in diameter. X-ray energy dispersive spectroscopy (EDS) analysis showed incorporation of silicon in Si-CCPC spheres. After soaking Si-CCPC spheres in simulated body fluid (SBF), hydroxycarbonate apatite formed on the Si-CCPC spheres. Inductively coupled plasma atomic emission spectroscopy (ICP-AES) showed that the Si4+ ion is released from Si-CCPC spheres in SBF.