Emulsion Technique Preparation of Nano-HA/PMMA Composites and In Vitro Evaluation

Abstract:

Nano-sized hydroxyapatite (HA) chloroform suspensions were firstly prepared by reactions in an emulsion system of Ca(OH)2-H3PO4-chloroform-lecithin, then, HA/PMMA composites with well dispersed HA could be obtained by adding PMMA into the suspension. The residual water in the HA suspension could lead to a porous surface which demonstrated better bioactivity in in vitro test. The residual water could cause HA particles to exist on pore walls during the composite formation, resulting in the increase of the HA amount per unit surfac

• Periodical: Key Engineering Materials (Volumes 309-311)
• Pages: 553-556
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.309-311.553
• Online since: May 2006
• Authors: Quan Hu, Hui Bin Liu, Wen Jian Weng, Kui Cheng, Chen Lu Song, Pi Yi Du, Gao Ling Zhao, Ge Shen, Jian Xun Wang, Gao Rong Han
• Keywords: Bioactivity, Emulsion, HA/PMMA, Synthesis

References

[1] S. Santavirta, M. Takagi, E. Gomez-Berrena, J. Nevalainen, J. Lassus, J. Salo, Y.T. Konttinen, J Long Term Eff Med Implants, 9(1999), p.67.

[2] M.J. Dalby, L. Di Silvio, E.J. Harper, W. Bonfield, Biomaterials, 23(2002), p.569.

[3] M.A.R. Freeman, G.W. Bradly, P.A. Ravell, J Bone Joint Surg. 64B(1982), p.489.

[4] T.W. Bauer, J. Schils, Skeletal Radiol., 28(1999), p.423.

[5] R.M. Meffert, Curr. Opin. Periodontol, 4(1997), p.104.

[6] P. Ducheyne, Q. Qiu, Biomaterials, 20(1999), p.2287.

[7] M. Yoshinari, T. Hayakawa, J.G.C. Wolke, K. Nemoto, J.A. Jansen, J. Biomed Mater Res., 37(1997), p.60.

[8] Q. Liu, J. R. de Wijn, C. A. van Blitterswijk, J Mater Sci Mater Med., 7(1996), p.551.

[9] Q. Liu, J. R. de Wijn, K. de Groot, C. A. van Blitterswijk, Biomaterials, 19(1998), p.1067.

[10] G. K. Lim, J. Wang, S.C. Ng and L.M. Gan, J. Mater. Chem., 9(1999), p.1635.