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Label-Free DNA Detection Using a Near-Field Microwave

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Abstract:

A near-field scanning microwave microscope (NSMM) is used to study the physical properties of DNA strands with a specific sequence and image lamda-DNA bundles. After the hybridization process between target and capture sequences, specific DNA binding events leads to microwave reflection coefficient (S11) changes of the NSMM. These changes are caused by a modification of the physical dielectric constant due to sequence specific DNA binding. This study demonstrates significant potential of the NSMM as a nondestructive and noncontact tool to detect DNA strands without a target-probe amplification process and as a valuable technique to understand the physical property of DNA.

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Info:

Periodical:

Key Engineering Materials (Volumes 321-323)

Pages:

1040-1043

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.321-323.1040

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Online since:

October 2006

Authors:

Kie Jin Lee, Arsen Babajayan, Song Hui Kim

Keywords:

Diagnostics, DNA, Label-Free, Near Field, Near-Field Scanning Microwave Microscope, Noncontact, Non-Destructive

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© 2006 Trans Tech Publications Ltd. All Rights Reserved

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