Setting Behaviors and Ciprofloxacin Hydrochloride Sustained Release of CSH-TCP Binary Cement

Abstract:

Calcium sulphate hemihydrate/α-tricalcium phosphate (CSH-TCP) cement are promising bone replacement materials with controllable-degradation rate and setting time and excellent delivery matrix for sustained release. In the present study, setting behaviors of binary bone cement composed of α-TCP and CSH and release of ciprofloxacin from this cement were investigated in vitro. XRD and SEM results demonstrated that the setting products of CSH-TCP cement were calcium sulphate dihydrate with pillar morphology and hydroxyapatite with needle morphology. Only 20% ciprofloxacin was released from CSH-TCP cement in 7 days in vitro. Fibers of hydroxyapatite enhanced strength of binary cement through fiber-reinforce mechanism. At initial stage (less than 100 hours), the release of ciprofloxacin from CSH-TCP cement was diffusion control, and at subsequent stage the release was matrix dissolution & diffusion control.

• Periodical: Key Engineering Materials (Volumes 330-332)
• Pages: 1017-1020
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.330-332.1017
• Online since: February 2007
• Authors: Dan Zhang, Qiang Cheng, Hui Li
• Keywords: Bone Cement, Calcium Sulphate Hemiydrate, Ciprofloxacin, Drug Release, α-Tricalcium Phosphate (α-TCP)

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