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HomeKey Engineering MaterialsKey Engineering Materials Vols. 330-332Hydroxyapatite/Chondoroitin Sulfate Microparticles...

Hydroxyapatite/Chondoroitin Sulfate Microparticles as Time-Controlled Release Carrier of Proteins

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Abstract:

Time-controlled releases of proteins from hydroxyapatite/chondroitin sulfate (HAp/ChS) spherical microparticles were achieved by the addition of zinc cation into the mixture solutions of HAp/ChS and protein as a novel formulation. The initial bursts of proteins, such as cytochrome c and bovine serum albumin, were apparently suppressed by the amount of zinc cation, which could be attributed to the formation of coordinate bonds of zinc cation among proteins and/or ChS moleculars. The increase of molecular lengths of ChS chains decreased the adsorbed amount of proteins, which did not apparently affected to the release of proteins.

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Bioceramics 19

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Periodical:

Key Engineering Materials (Volumes 330-332)

Pages:

1009-1012

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.330-332.1009

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Online since:

February 2007

Authors:

Hajime Watanabe, Toshiyuki Ikoma, Guo Ping Chen, M. Tanaka

Keywords:

Chondroitin Sulfate, Composite, Hydroxyapatite (HAP), Microparticle, Protein, Sustained Release, Zinc

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© 2007 Trans Tech Publications Ltd. All Rights Reserved

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[10] A. Ito et al. Mater. Sci. & Eng. C 22 (2002), pp.21-25 Fig. 3 Release patterns of the model proteins from the microparticles formulated with zinc cation; (a) Hb, (b) cyt c and (c) LYZ (n=4). (b) (a) (c).

0. 5.

[1] 1. 5.

[2] 2. 5 0 20 40 60 80 100 120 140 160 180.

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[1] 1. 5.

[2] 2. 5 0 20 40 60 80 100 120 140 160 180.

[2] [4] [6] [8] [10] [12] [14] [16] 0 20 40 60 80 100 120 140 160 180.

[2] [4] [6] [8] [10] [12] [14] [16] 0 20 40 60 80 100 120 140 160 180.

[40] [50] [60] [70] [80] [90] 100 0 20 40 60 80 100 120 140 160 180.

[40] [50] [60] [70] [80] [90] 100 0 20 40 60 80 100 120 140 160 180 Soaking time (hour) Soaking time (hour) Soaking time (hour) Rate of released protein (%) Rate of released protein (%) Rate of released protein (%) HAp+3Zn HAp/ChS(15kDa)2%+3Zn HAp/ChS(20kDa)2%+3Zn HAp/ChS(35kDa)2%+3Zn HAp+3Zn HAp/ChS(15kDa)2%+3Zn HAp/ChS(20kDa)2%+3Zn HAp/ChS(35kDa)2%+3Zn HAp+3Zn HAp/ChS(15kDa)2%+3Zn HAp/ChS(20kDa)2%+3Zn HAp/ChS(35kDa)2%+3Zn HAp+3Zn HAp/ChS(15kDa)2%+3Zn HAp/ChS(20kDa)2%+3Zn HAp/ChS(35kDa)2%+3Zn.

DOI: 10.4028/www.scientific.net/amr.581-582.463