Hydroxyapatite/Chondoroitin Sulfate Microparticles as Time-Controlled Release Carrier of Proteins
Time-controlled releases of proteins from hydroxyapatite/chondroitin sulfate (HAp/ChS) spherical microparticles were achieved by the addition of zinc cation into the mixture solutions of HAp/ChS and protein as a novel formulation. The initial bursts of proteins, such as cytochrome c and bovine serum albumin, were apparently suppressed by the amount of zinc cation, which could be attributed to the formation of coordinate bonds of zinc cation among proteins and/or ChS moleculars. The increase of molecular lengths of ChS chains decreased the adsorbed amount of proteins, which did not apparently affected to the release of proteins.
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
H. Watanabe et al., "Hydroxyapatite/Chondoroitin Sulfate Microparticles as Time-Controlled Release Carrier of Proteins", Key Engineering Materials, Vols. 330-332, pp. 1009-1012, 2007