This study examined the role of tissue adhesives during early healing and the effects of tooth ash and plaster of Paris on bone healing in the presence of osteoporosis. Sixty rats were assigned to five groups randomly and each group was further divided into two subgroups, which were examined 4 and 8 weeks after implantation. Histologic sections and histomorphometric analysis of defects were obtained 4 and 8 weeks after surgery. Bone formation was significantly better in the non-ovariectomized groups compared to the ovariectomized group. A mixture of tooth ash and plaster of Paris is recommended, but not tissue adhesives, in ovariectomized cases.