Improvement of Biocompatibility and Osteointegration of Zirconia Implants by Means of Bioactive Glass Coating: An Experimental Study in Animal
The present work aimed to evaluate the biological properties between the bioglass coated and uncoated zirconia implants. A total of 24 implants were retrieved. Bioglass coated and uncoated porous implants were implanted in the mandible of 4 dogs. At the experimental times of 4 and 8 weeks after sacrifice, the histological sections specimens of the implants and surrounding tissues were processed to determine the osteointegration rate; The other corresponding implants were processed for SEM microanalysis. A significantly higher affinity index was demonstrated in vivo by histomorphometric evaluation in coated versus uncoated implants. The osteointegration rates varied between 21.5% and 47.7% (cancellous bone), and between 28.0% and 56.8% (cortical bone). (p < 0.05). SEM analysis demonstrated better bone adhesion to the material in coated implant at any weeks. Coated implants are highly biocompatible and osteoconductive.
Wei Pan and Jianghong Gong
D.W. Yang et al., "Improvement of Biocompatibility and Osteointegration of Zirconia Implants by Means of Bioactive Glass Coating: An Experimental Study in Animal", Key Engineering Materials, Vols. 336-338, pp. 1679-1682, 2007