Ozone-Induced Immobilization of Chitosan and Heparin on Polyethylene Terephthalate Films to Improve Antithrombogenic Properties

Jian Xin Li; Jin Wang; Peng Li; Ya Jun Weng; Ling Ren; Xue Ling Fei; Hong Sun; Nan Huang

doi:10.4028/www.scientific.net/KEM.342-343.809

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Coating of Anionic Phospholipid Polymer onto Silica-Based Microchannel to Minimize Nonspecific Protein Adsorption
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Improving Blood Compatibility of Cardiovascular Devices by Surface Modification
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Blood Compatibility of Novel Zwitterionic PEG-Grafted Nitinol Alloy for Peripheral Arterial Stents
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Ozone-Induced Immobilization of Chitosan and Heparin on Polyethylene Terephthalate Films to Improve Antithrombogenic Properties
p.809

Effect of Solvent on the Characteristics of Electrospun Regenerated Silk Fibroin Nanofibers
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Preparation and Characterization of β-Tricalcium Phosphate Nanofibers via Electrospinning
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Study of Protein Adsorption on Biomaterial Surfaces by SPR
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Ozone-Induced Immobilization of Chitosan and Heparin on Polyethylene Terephthalate Films to Improve Antithrombogenic Properties

Abstract:

of artificial blood catheters. This paper describes the immobilization of chitosan and heparin molecules on polyethylene terephthalate (PET) films by ozonization. The concentration of peroxide groups (-OOH) was 1.72 × 10-7 mol/cm2 on the PET surface oxidized by ozonization. The results of X-ray photoelectron spectroscopy (XPS) indicate that chains of chitosan and heparin were successfully immobilized on the PET films. The static contact angle(STA) of water decreases from 83.5° to 68.3° by immobilization of chitosan and heparin, which means that the hydrophilic properties of the modified PET is improved. The antithrombogenic property of PET surface was evaluated by a platelet-rich plasma (PRP) adhesion test. The results indicate that the number of platelet adhered on the modified-PET surface incubated with PRP for 240 min decreased significantly and platelets did not aggregate and distort.