Ozone-Induced Immobilization of Chitosan and Heparin on Polyethylene Terephthalate Films to Improve Antithrombogenic Properties
of artificial blood catheters. This paper describes the immobilization of chitosan and heparin molecules on polyethylene terephthalate (PET) films by ozonization. The concentration of peroxide groups (-OOH) was 1.72 × 10-7 mol/cm2 on the PET surface oxidized by ozonization. The results of X-ray photoelectron spectroscopy (XPS) indicate that chains of chitosan and heparin were successfully immobilized on the PET films. The static contact angle(STA) of water decreases from 83.5° to 68.3° by immobilization of chitosan and heparin, which means that the hydrophilic properties of the modified PET is improved. The antithrombogenic property of PET surface was evaluated by a platelet-rich plasma (PRP) adhesion test. The results indicate that the number of platelet adhered on the modified-PET surface incubated with PRP for 240 min decreased significantly and platelets did not aggregate and distort.
Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon
J. X. Li et al., "Ozone-Induced Immobilization of Chitosan and Heparin on Polyethylene Terephthalate Films to Improve Antithrombogenic Properties", Key Engineering Materials, Vols. 342-343, pp. 809-812, 2007