Ozone-Induced Immobilization of Chitosan and Heparin on Polyethylene Terephthalate Films to Improve Antithrombogenic Properties

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of artificial blood catheters. This paper describes the immobilization of chitosan and heparin molecules on polyethylene terephthalate (PET) films by ozonization. The concentration of peroxide groups (-OOH) was 1.72 × 10-7 mol/cm2 on the PET surface oxidized by ozonization. The results of X-ray photoelectron spectroscopy (XPS) indicate that chains of chitosan and heparin were successfully immobilized on the PET films. The static contact angle(STA) of water decreases from 83.5° to 68.3° by immobilization of chitosan and heparin, which means that the hydrophilic properties of the modified PET is improved. The antithrombogenic property of PET surface was evaluated by a platelet-rich plasma (PRP) adhesion test. The results indicate that the number of platelet adhered on the modified-PET surface incubated with PRP for 240 min decreased significantly and platelets did not aggregate and distort.

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Periodical:

Key Engineering Materials (Volumes 342-343)

Edited by:

Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon

Pages:

809-812

Citation:

J. X. Li et al., "Ozone-Induced Immobilization of Chitosan and Heparin on Polyethylene Terephthalate Films to Improve Antithrombogenic Properties", Key Engineering Materials, Vols. 342-343, pp. 809-812, 2007

Online since:

July 2007

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$38.00

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