In Vitro and In Vivo Biological Behavior of CDHA/OCP/β-TCP Scaffold

Ana Maria Minarelli Gaspar; Sybele Saska; J. Jimenez; L.R. da Cunha; P.D.A. Bolini; Claudinete V. Leal; L. Morejón-Alonso; R. García Carrodeguas; A. López-Bravo; Cecília A.C. Zavaglia

doi:10.4028/www.scientific.net/KEM.361-363.1127

Paper Titles

Preliminary Results of In Vitro Study of Cell Growth in a 45S5 Bioactive Glass as Bone Substitute Using Scanning Electron and Confocal Microscopies
p.1111

Initial Attachment of MC3T3-E1 Cells on Nano-HAp Surfaces
p.1115

Protein Adsorption on Hydroxyapatite Nano-Crystals with Quartz Crystal Microbalance Technique
p.1119

Is Hydroxyapatite Ceramic Included in the Bone Remodelling Proccess? An In Vitro Study of Resorption and Formation Processes
p.1123

In Vitro and In Vivo Biological Behavior of CDHA/OCP/β-TCP Scaffold
p.1127

Cell Growth on TiAlNb Alloy as a Function of Bioactivation Method
p.1131

Cytotoxicity Analysis of Apatites Modified with Divalent Metals
p.1135

Effect of Sintering Process of HA/TCP Bioceramics on Microstructure, Dissolution, Cell Proliferation and Bone Ingrowth
p.1139

Characterization of Bone Cell Behaviors on Collagen Grafted Hydroxyapatite Surfaces
p.1143

HomeKey Engineering MaterialsKey Engineering Materials Vols. 361-363In Vitro and In Vivo Biological Behavior of...

In Vitro and In Vivo Biological Behavior of CDHA/OCP/β-TCP Scaffold

Abstract:

The biological behavior of a new bioactive material composed of calcium-deficient hydroxyapatite, octacalcium phosphate, and β-tricalcium phosphate was investigated by in vitro indirect and direct cytotoxicity, cell adhesion and proliferation tests, and by in vivo subcutaneous and bone implantation in rats. The results of the in vitro studies showed that the material is biocompatible and no cytotoxic. Slightly poorer initial cell adhesion and lower cell proliferation than in control was observed, which were attributed to the reactivity and roughness of the material surface. In vivo results showed that the material is biodegradable and bioactive in bone tissue, but only biocompatible and partially biodegradable in soft tissue.

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Periodical:

Key Engineering Materials (Volumes 361-363)

Pages:

1127-1130

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.361-363.1127

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Online since:

November 2007

Authors:

Ana Maria Minarelli Gaspar, Sybele Saska, J. Jimenez, L.R. da Cunha, P.D.A. Bolini, Claudinete V. Leal, L. Morejón-Alonso, R. García Carrodeguas, A. López-Bravo, Cecília A.C. Zavaglia

Keywords:

Calcium Deficient Hydroxyapatite, In Vitro, In Vivo, Octacalcium Phosphate, β-Tricalcium Phosphate (β-TCP)

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