Novel Composite of Nano-Sized SiO2/Chitosan Induce the Growth of HAp Crystal
A novel hybrid material of chitosan/nano-sized SiO2/hydroxyapatite (HAp) composite was prepared through a biomimetic approach. HAp deposited in situ on the surface of chitosan/ nano-sized SiO2 composite film in simulate body fluid (SBF) solution at 36.5°C. The X-ray diffraction (XRD) and scanning electron microscopy (SEM) were performed to study composition and morphological characteristics of the HAp crystal. The results indicated that nano-sized SiO2 dispersed in the chitosan film provided initial nucleation sites for the growth of the HAp in SBF solution by adsorbing further PO4 3−, Ca2+ due to the induction of HAp formed. The strength of the composite was largely improved because of the addition of nano-sized SiO2.
Guy Daculsi and Pierre Layrolle
S. W. Huang et al., "Novel Composite of Nano-Sized SiO2/Chitosan Induce the Growth of HAp Crystal ", Key Engineering Materials, Vols. 361-363, pp. 483-486, 2008