In this research paper, the cyclic stress amplitude controlled fatigue response and fracture behavior of an Al-Cu (Aluminum Association designation 2219) is presented and discussed. The alloy was provided as a thin sheet in the T62 temper in the fully anodized condition. A small quantity of the as-provided sheet was taken and the surface carefully prepared to remove the thin layer of anodized coating. Test specimens of the alloy, prepared from the two sheets (anodized and non-anodized), were cyclically deformed under stress amplitude control at two different load ratios with the primary objective of establishing the conjoint influence of magnitude of cyclic stress, load ratio and intrinsic microstructural effects on cyclic fatigue life and final fracture characteristics. The high cycle fatigue resistance of the alloy is described in terms of maximum stress, load ratio, and microstructural influences on strength. The final fracture behavior of the alloy sheet is discussed in light of the concurrent and mutually interactive influences of intrinsic microstructural effects, deformation characteristics of the alloy microstructure, magnitude of cyclic stress, and resultant fatigue life.