Polymeric Calcium Phosphate Cements Incorporated with Poly-γ-Glutamic Acid

Abstract:

Polymeric calcium phosphate cements (PCPC) derived from biodegradable poly-g-glutamic acid (g-PGA) were prepared in an attempt to improve the mechanical strength of calcium phosphate cement (CPC). The characteristics of the PCPCs were compared to those of cement incorporated with citric acid. The diametral tensile and compressive strengths of the CPC incorporated with g-PGA were significantly higher than that of cement incorporated with citric acid at equivalent concentrations (p<0.05). The maximal diametral tensile and compressive strengths of the CPC incubated for 1 week in physiological saline solution were approximately 18.0 and 50.0 MPa, respectively. However, the initial setting time of the PCPC was much slower than that of CPC incorporated with citric acid. The formation of ionic complexes between calcium ions and g-PGA was observed using FT-IR spectroscopy. Hydroxyapatite (HA) formation was retarded by g-PGA incorporation according to scanning electronic microscopy (SEM) and powder X-ray diffraction (XRD) observations.

• Periodical: Key Engineering Materials (Volumes 396-398)
• Pages: 265-268
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.396-398.265
• Online since: October 2008
• Authors: Sung Soo Kim, Sung Jae Lee, Yong Sik Kim, Kwon Yong Lee
• Keywords: Calcium Phosphate Cement (CPC), Poly-Gamma-Glutamic Acid, Tricalcium Phosphate

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