Visualization of Invasion into the Body and Internal Diffusion of Nanoparticles

Fumio Watari; Shigeaki Abe; I.D. Rosca; Atsuro Yokoyama; Motohiro Uo; T. Akasaka; N. Takashi; Y. Totsuka; E. Hirata; M. Matsuoka; K. Ishikawa; S. Itoh; Y. Yawaka

doi:10.4028/www.scientific.net/KEM.396-398.569

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HomeKey Engineering MaterialsKey Engineering Materials Vols. 396-398Visualization of Invasion into the Body and...

Visualization of Invasion into the Body and Internal Diffusion of Nanoparticles

Abstract:

Nanoparticles may invade directly into the internal body through the respiratory or digestive system and diffuse inside body. The behavior of nanoparticles in the internal body is also essential to comprehend for the realization of DDS. Thus it is necessary to reveal the internal dynamics for the proper treatments and biomedical applications of nanoparticles. In the present study the plural methods with different principles such as X-ray scanning analytical microscope (XSAM), MRI and Fluorescent microscopy were applied to enable the observation of the internal diffusion of micro/nanoparticles in the (1) whole body level, (2) inner organ level and (3) tissue and intracellular level. Chemical analysis was also done by ICP-AES for organs and compared with the results of XSAM mapping.

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Periodical:

Key Engineering Materials (Volumes 396-398)

Pages:

569-572

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.396-398.569

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Online since:

October 2008

Authors:

Fumio Watari, Shigeaki Abe, I.D. Rosca, Atsuro Yokoyama, Motohiro Uo, T. Akasaka, N. Takashi, Y. Totsuka, E. Hirata, M. Matsuoka, K. Ishikawa, S. Itoh, Y. Yawaka

Keywords:

DDS, Internal Diffusion, Mapping, Nanoparticle, Nanotoxicology, Size Effect

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References

[1] F. Watari, K. Tamura, A. Yokoyama, K. Shibata, T. Akasaka, B. Fugetsu, K. Asakura, M. Uo, Y. Totsuka, Y. Sato, K. Tohji: Handbook of Biomineralization, Vol. 3, Ed.E. Bauerlein, WileyVCH, Weinheim, pp.127-144 (2007).

DOI: 10.1002/9783527619443.ch53

Google Scholar

[2] M. Uo, F. Watari, A. Yokoyama, H. Matsuno, T. Kawasaki: Biomaterials 20(1999), 747-755.

DOI: 10.1016/s0142-9612(98)00224-5

Google Scholar

[3] M. Uo, M. Tanaka, F. Watari: J. Biomed. Mater. Res. Part B: Appl. Biomater. 70B(2004), 146-151.

Google Scholar

[4] M. Ushiro, K. Uno, T. Fujikawa, Y. Sato, K. Tohji, F. Watari, W. Chun, Y. Koike, K. Asakura: Phys. Rev. B 73, 144103/1-11(2006).

DOI: 10.1103/physrevb.73.144103

Google Scholar

[5] Aoki N, Akasaka T, Watari F, Yokoyama A, Dent. Mat.J., 26 (2007) 178-185.

Google Scholar

[6] A. Yokoyama, Y. Sato, Y. Nodasaka, S. Yamamoto, T. Kawasaki, M. Shindoh, T. Kohgo, T. Akasaka, M. Uo, F. Watari, K. Tohji: Nano Letters 5 (2005) , 157-161.

DOI: 10.1021/nl0484752

Google Scholar

[7] F. Watari, S. Abe, C. Koyama, A. Yokoyama, T. Akasaka, M. Uo, M. Matsuoka, Y. Totsuka, M. Esaki, M. Morita, T. Yonezawa: J. Cera. Soc. Jap., 116 (1) , 1-5, (2008).

DOI: 10.2109/jcersj2.116.1

Google Scholar

[8] R. Kumazawa, F. Watari, N. Takashi, Y. Tanimura, M. Uo, Y. Totsuka: Biomaterials 23(2002), 3757-3764.

DOI: 10.1016/s0142-9612(02)00115-1

Google Scholar

[9] K. Tamura, N. Takashi, R. Kumazawa, F. Watari, Y. Totsuka: Mat. Trans. 43(2002), 3052-3057.

Google Scholar

[10] F. Watari, S. Abe, K. Tamura, M. Uo, A. Yokoyama, Y. Totsuka: Bioceramics Vol. 20 Part 1, (Key Engineering Materials Vols. 361-363), Trans. Tech. Publ., pp.95-98, (2007).

Google Scholar