In Vivo Performance of an Injectable Biphasic Calcium Phosphate Bone Filler

Abstract:

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An hydrated putty was prepared by mixing submicron particles, rounded particles and granules of Biphasic Calcium Phosphate (BCP) ceramics composed of HA and β-TCP phases. The material filled entirely critical sized defects in the femoral epiphysis of NZW rabbits. After 3, 6 and 12 weeks, histology revealed that submicron particles were rapidly degraded by multinucleated TRAP-positive cells. This osteoclastic resorption stimulated bone ingrowth while the large BCP particles served as scaffold supporting bone healing by osteoconduction.

Info:

Periodical:

Key Engineering Materials (Volumes 396-398)

Main Theme:

Edited by:

Marcelo Prado and Cecília Zavaglia

Pages:

583-586

DOI:

10.4028/www.scientific.net/KEM.396-398.583

Citation:

P. Layrolle et al., "In Vivo Performance of an Injectable Biphasic Calcium Phosphate Bone Filler", Key Engineering Materials, Vols. 396-398, pp. 583-586, 2009

Online since:

October 2008

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Price:

$35.00

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