In Vivo Performance of an Injectable Biphasic Calcium Phosphate Bone Filler

Pierre Layrolle; Serge Baroth; Eric Goyenvalle; Eric Aguado; Françoise Moreau; Guy Daculsi

doi:10.4028/www.scientific.net/KEM.396-398.583

Paper Titles

The Relationship of the Oxide Phases on Irradiated Titanium Surface by Nd:YVO₄ Laser with the Ca,P Deposited Layer
p.565

Visualization of Invasion into the Body and Internal Diffusion of Nanoparticles
p.569

Effect of Surface Treatments on Bonding Strength of Zirconia to Dental Cements
p.575

Formation of Hydroxyapatite Nanosized and other Apatites by Electrolysis Process
p.579

In Vivo Performance of an Injectable Biphasic Calcium Phosphate Bone Filler
p.583

Influence of Processing on Mechanical Properties of Hydroxyapatite
p.587

Obtainment of α-Tricalcium Phosphate by Solution Combustion Synthesis Method Using Urea as Combustible
p.591

Phase Evolution of Thermally Treated Amorphous Tricalcium Phosphate Nanoparticles
p.595

Preparation and Characterization of Nanoporous Alumina Membrane Made by Two-Step Anodization
p.599

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In Vivo Performance of an Injectable Biphasic Calcium Phosphate Bone Filler

Abstract:

An hydrated putty was prepared by mixing submicron particles, rounded particles and granules of Biphasic Calcium Phosphate (BCP) ceramics composed of HA and β-TCP phases. The material filled entirely critical sized defects in the femoral epiphysis of NZW rabbits. After 3, 6 and 12 weeks, histology revealed that submicron particles were rapidly degraded by multinucleated TRAP-positive cells. This osteoclastic resorption stimulated bone ingrowth while the large BCP particles served as scaffold supporting bone healing by osteoconduction.