In Vivo Performance of an Injectable Biphasic Calcium Phosphate Bone Filler
An hydrated putty was prepared by mixing submicron particles, rounded particles and granules of Biphasic Calcium Phosphate (BCP) ceramics composed of HA and β-TCP phases. The material filled entirely critical sized defects in the femoral epiphysis of NZW rabbits. After 3, 6 and 12 weeks, histology revealed that submicron particles were rapidly degraded by multinucleated TRAP-positive cells. This osteoclastic resorption stimulated bone ingrowth while the large BCP particles served as scaffold supporting bone healing by osteoconduction.
Marcelo Prado and Cecília Zavaglia
P. Layrolle et al., "In Vivo Performance of an Injectable Biphasic Calcium Phosphate Bone Filler", Key Engineering Materials, Vols. 396-398, pp. 583-586, 2009