The deep hole honing is an effective and precise method in deep hole processing. It can remove the machining allowance to ensure the hole size and the shape accuracy, and have better surface quality of a hole. The difficult-to-cut materials such as precipitation-hardening stainless steel, stainless steel (1Cr18Ni9Ti) and titanium alloy have the properties of high hardness, wear resistance, heat resistance, and corrosion resistance. The conventional single-abrasive honing stones can not handle the difficult-to-cut materials effectively because of their single-abrasive property. For higher efficiency, more than ten of mixture-abrasive honing stones with different proportion of different abrasives have been designed and the contrast experiments have been done for different mixture-abrasive honing stones to grind precipitation-hardening stainless steel, stainless steel (1Cr18Ni9Ti) and titanium alloy. According to several comprehensive evaluation factors of the grinding ratio, the specific grinding energy and the area that the honed chips stick the oilstones surface, the optimum proportion of different abrasives have been found for honing difficult-to-cut materials. It can be observed that the mixture-abrasive honing stones have better performance than that of single-abrasive stones when honing certain kind of difficult-to-cut materials.