The measurement of engine cylinder joint surface holes is directly related to the control of product quality and the follow-up assembly. CMM is widely used in this field but can not meet the inspection requirements of automation, rapidity and Online testing. In this paper, a new measurement scheme based on the combination of multi-vision sensors is proposed. The global calibration method is focused on and a new dedicated calibration target is designed. The whole process of the system global calibration can be accomplished quickly through single imaging. The experiment results show that the method is feasible and with high precision. The method mentioned above can satisfy the engine production line requirements of intelligence, rapidity, high precision and low cost.