Next-generation cellular networks will provide higher cell capacity by adopting advanced physical layer techniques and bandwidth. In such networks, low throughput due to severe inter-cell interference and unbalanced user distributions among cells couldn’t be born. In this paper, we focus on solving this problem by adopting a novel self-adaptive handover parameters adjustment and load-balancing schemes in LTE systems. The core idea is to obtain the empirical data of network operations and the load distribution of the high load cell to carry out pre-adjustment between the high load cell and its neighbors. Accordingly, the effect of adjustment is evaluated and parameter adjustment strategy sets will be carried out to complete update based on results of the evaluation. The scheme could consume less networks resource and implement dynamic load balance effectively.