Control of Antibiotic Delivery from TCP along with HA on Bone Cement in the Interface Bioactive Bone Cement for Prevention of Infection in Joint Replacement

Abstract:

Since 1985, HA granules were interposed on the interface between bone and bone cement at the cementation (Interface Bioactive Bone Cement : IBBC) in THA to prevent generation of connective tissue and osteolysis. To prevent infection, β-TCP impregnated with antibiotics along with HA granules was used. As TCP is resorbable, antibiotic release can be controlled. β-TCP granules were impregnated with antibiotics of folmoxef sodium (F), Vancomycine hydrochloride (V) cefortiam dihydrochloride (C) and cefozopran hydrochloride (CE). Three models of antibiotic release were assumed. Model [1] was antibiotic release from surroundings of β-TCP granules. Model [2] was the condition loaded under normal and reduced pressure. In Model [3], β-TCP was dissolved gradually in EDTA, as the model in the living body. In model [1], the amount of release of F, V and C was 3280, 300 and 3 µg, respectively and completed in 30 hours. In model [2], the amount of release of F, V, C and CE was 16, 8, 0 and 8000 µg in reduced pressure, respectively. The release of F, V and C completed within 24 hours and that of CE was in 6 days. In model [3], released amount of C and CE was 116 and 7100 µg, respectively and completed in 19 days.

• Periodical: Key Engineering Materials (Volumes 493-494)
• Pages: 186-190
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.493-494.186
• Online since: October 2011
• Authors: Shigekazu Mizokawa, Tomonori Arita, Akira Tachibana, Toshizumi Tanabe, Hiroyuki Oonishi Jr., Hironobu Oonishi
• Keywords: Antibiotics, Bone Cement, IBBC, Infection, THA, β-TCP

References

[1] B.M. Wroblewski: Clin Orthop 210, 37, (1985).

[2] H. Oonishi et al: Bioceramics – 1, 102, (1981).

[3] H. Oonishi et al: J Arthroplasty, 16, 784, (2001).

[4] H. Oonishi et al: J Appl Biomat, 53, 174, (2000).

[5] H. Oonishi et al: Clin Orthop, 466, 373, (2008).

[6] H. Oonishi Jr. et al: Bioceramics – 22, 729, (2009).