In Vitro Dynamic Degradation of Strontium-Hydroxyapatite Granules
The knowledge of the degradation process is an important role to understand and predict in vitro results. Granules of strontium-hydroxyapatite (Sr-HA) were submitted to a degradation process under dynamic conditions using a bioreactor system and using a solution with pH=5. The degradation process under dynamic conditions can be represented by a curve in which the calcium content firstly increases (dissolution part) followed by calcium decreasing (reprecipitation). The use of a low pH solution does not affect the curve’s shape but reduces the precipitation step.
Eyup Sabri Kayali, Gultekin Goller and Ipek Akin
H. M. da Silva et al., "In Vitro Dynamic Degradation of Strontium-Hydroxyapatite Granules", Key Engineering Materials, Vols. 493-494, pp. 205-208, 2012