In Vitro Evaluations of a Mechanically Optimized Calcium Phosphate Cement as a Filler for Bone Repair

Nader Nezafati; F. Moztarzadeh; Masoud Mozafari

doi:10.4028/www.scientific.net/KEM.493-494.209

Paper Titles

Preparation and Characterization of Calcium Phosphate Crystals by Precursor Thermolysis Method
p.191

Gallium-Doped β-Tricalcium Phosphate Ceramics: Characterization and Properties
p.195

Effect of Al₂O₃, ZrO₂, and TiO₂ Addition on the Mechanical Properties and the Microstructure of Natural Hydroxyapatite Obtained from Calf Femoral Bone
p.199

In Vitro Dynamic Degradation of Strontium-Hydroxyapatite Granules
p.205

In Vitro Evaluations of a Mechanically Optimized Calcium Phosphate Cement as a Filler for Bone Repair
p.209

Preparation of Submicron-Sized Hydroxyapatite Powders by Spray Pyrolysis
p.215

Recrystallization of Amorphized α-TCP
p.219

Raman and Infrared Studies of Substituted β-TCP
p.225

The Effect of Microwave Irradiation on Structural and Mechanical Properties of Nano-Structured Bone-Like Carbonated Hydroxyapatite
p.231

HomeKey Engineering MaterialsKey Engineering Materials Vols. 493-494In Vitro Evaluations of a Mechanically Optimized...

In Vitro Evaluations of a Mechanically Optimized Calcium Phosphate Cement as a Filler for Bone Repair

Abstract:

Basic drawbacks of calcium phosphate cements (CPCs) are the brittleness and low strength behavior which prohibit their use in many stress-bearing locations, unsupported defects, or reconstruction of thin bones. Recently, to solve these problems, researchers investigated the incorporation of fibers into CPCs to improve their strength. In the present study, various amounts of a highly bioactive glass fiber were incorporated into calcium phosphate bone cement. The obtained results showed that the compressive strength of the set cements without any fibers optimally increased by further addition of the fiber phase. Also, both the work-of-fracture and elastic modulus of the cement were considerably increased after applying the fibers in the cement composition. Herein, with the aim of using the reinforced-CPC as appropriate bone filler, the prepared sample was evaluated in vitro using simulated body fluid (SBF) and osteoblast cells. The samples showed significant enhancement in bioactivity within few days of immersion in SBF solution. Also, in vitro experiments with osteoblast cells indicated an appropriate penetration of the cells, and also the continuous increase in cell aggregation on the samples during the incubation time demonstrated the ability of the reinforced-CPC to support cell growth. Therefore, we concluded that this filler and strong reinforced-CPC may be beneficial to be used as bone fillers in surgical sites that are not freely accessible by open surgery or when using minimally invasive techniques.

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Key Engineering Materials (Volumes 493-494)

Pages:

209-214

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.493-494.209

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Online since:

October 2011

Authors:

Nader Nezafati, F. Moztarzadeh, Masoud Mozafari

Keywords:

Bioactive Glass Fiber, Bone-Like Apatite, Calcium Phosphate Cement (CPC), In Vitro, Tissue Engineering

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