Poly(lactic-co-glycolic)/Nanostructured Merwinite Porous Composites for Bone Tissue Engineering. I. Preparation and Morphology

Abstract:

A novel merwinite/ Poly(lactic-co-glycolic) nanocomposite was synthesized by a solvent casting/salt leaching technique with varying merwinite contents from 10 to 30% (w/w). Poly(lactic-co-glycolic) /merwinite foams with a co-continuous structure of interconnected pores were formed. The microstructure of the pores and the walls was controlled by varying the merwinite content. The pore structure becomes more and more irregular with increasing merwinite content. Pore sizes ranging from several microns to a few hundred microns were obtained. The degradation assessment of the scaffolds is performed in phosphate-buffered saline (PBS) solution at 37°C. Weight loss during storage at 37°C in PBS (pH 7.4) was determined for the scaffolds. Weight loss increased from pure to high content during incubation time. The prepared merwinite/ (Polylactic-co-glycolic) nanocomposite with uniform microstructure may be used in bone tissue engineering applications.

• Periodical: Key Engineering Materials (Volumes 493-494)
• Pages: 718-722
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.493-494.718
• Online since: October 2011
• Authors: Masoud Hafezi-Ardakani, Faranak Kavian, Fatollah Moztarzadeh, Mohamadreza Baghaban Eslaminejad, Ali Zamanian, Fatemeh Bagheri
• Keywords: Bioceramic, Merwinite, PLGA, Scaffold

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